Trave Ilaria, Micalizzi Claudia, Cozzani Emanuele, Gasparini Giulia, Parodi Aurora
Section of Dermatology - Department of Health Sciences, University of Genoa, IRCCS - Ospedale Policlinico San Martino, Genoa, Italy.
Dermatol Pract Concept. 2022 Oct 1;12(4):e2022201. doi: 10.5826/dpc.1204a201. eCollection 2022 Nov.
Topical ivermectin is an anti-inflammatory and anti-Demodex drug for papulopustular rosacea. Rosacea is a relapsing disease and the time between recurrences should be considered alongside efficacy.
The aims of this study were to assess the time of first relapse and relapse rates of Demodex mite infestation and papulopustular rosacea.
We conducted a prospective study of subjects affected by different degrees of papulopustular rosacea. Patients that achieved a complete response after treatment were monitored every 4 weeks and up to 32 additional weeks. For each patient, we evaluated recording the time to first relapse and relapse rate of Demodex mite infestation and rosacea.
The overall success rate on Demodex infestation was 87.5% only 12.5% relapse. Ivermectin leads to complete response in 70% of patients. Median time to relapse was 140 days, the mean time was 152 days. The global success rate was 54.76%.
Topical ivermectin keeps a remission of Demodex infestation and clinical remission for long time. We proposed a twice weekly ivermectin maintenance therapy to reduce recurrences.
外用伊维菌素是一种用于治疗丘疹脓疱型酒渣鼻的抗炎和抗蠕形螨药物。酒渣鼻是一种复发性疾病，复发间隔时间应与疗效一并考虑。
本研究旨在评估首次复发时间以及蠕形螨感染和丘疹脓疱型酒渣鼻的复发率。
我们对不同程度的丘疹脓疱型酒渣鼻患者进行了一项前瞻性研究。治疗后达到完全缓解的患者每4周监测一次，最多持续32周。对于每位患者，我们评估记录首次复发时间以及蠕形螨感染和酒渣鼻的复发率。
蠕形螨感染的总体成功率为87.5%，仅12.5%复发。伊维菌素使70%的患者达到完全缓解。复发的中位时间为140天，平均时间为152天。总体成功率为54.76%。
外用伊维菌素可使蠕形螨感染长期缓解并使临床症状长期缓解。我们建议采用每周两次的伊维菌素维持疗法以减少复发。
