抗坏血酸介导的主要牛乳腺炎病原菌抗生素敏感性调节
Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens.
作者信息
Liang Zeyi, Shen Jiahao, Liu Jing, Li Qinfan, Yang Feng, Ding Xuezhi
机构信息
Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou, People's Republic of China.
College of Veterinary Medicine, Northwest A&F University, Shaanxi, People's Republic of China.
出版信息
Infect Drug Resist. 2022 Dec 14;15:7363-7367. doi: 10.2147/IDR.S388023. eCollection 2022.
Abstract
This study aimed to investigate the effects of ascorbic acid on antibiotic susceptibility of major bovine mastitis pathogens, including , and . Minimum inhibitory concentrations (MICs) were determined by E-test method. The presence of 10 mM ascorbic acid decreased the MICs of penicillin and ampicillin while increased the MICs of erythromycin, kanamycin, streptomycin, and ciprofloxacin for all tested strains. Besides, ascorbic acid specifically reduced the MICs of tetracycline for gram-positive bacteria and chloramphenicol for gram-negative bacteria. This study highlights that ascorbic acid is a potential modulator of antibiotic activity against the major bovine mastitis pathogens.
摘要
本研究旨在调查抗坏血酸对主要牛乳腺炎病原体（包括 、 和 ）抗生素敏感性的影响。采用E-test法测定最低抑菌浓度（MICs）。对于所有测试菌株，10 mM抗坏血酸的存在降低了青霉素和氨苄青霉素的MICs，同时提高了红霉素、卡那霉素、链霉素和环丙沙星的MICs。此外，抗坏血酸特异性降低了革兰氏阳性菌对四环素和革兰氏阴性菌对氯霉素的MICs。本研究强调，抗坏血酸是针对主要牛乳腺炎病原体的抗生素活性的潜在调节剂。
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