Peng Hongjun, Zeng Yi
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Dec 15;36(12):1549-1557. doi: 10.7507/1002-1892.202209015.
To review the research progress on the correlation between sarcopenia and osteoarthritis (OA).
The basic and clinical studies at home and abroad in recent years on sarcopenia and OA were extensively reviewed. The correlation between sarcopenia and OA was analyzed and summarized from five aspects: epidemiological status, risk factors, pathogenesis, clinical treatments, and the impact on joint arthroplasty.
Sarcopenia and OA are common diseases in the elderly with high prevalence and can increase the ill risk of each other. They share a set of risk factors, and show negative interactive and influence on pathogenesis and clinical treatments, thus participating in each other's disease process and reducing the treatment benefits. Clinical studies show that sarcopenia can affect the rehabilitation effect and increase the risk of postoperative complications after total joint arthroplasty in many ways.
Current research results show that sarcopenia and OA are related and can be mutually affected in the above 5 aspects, but more studies are needed to further clarify the relationship between them, so as to provide more theoretical basis for the understanding, prevention, diagnosis, and treatments of the two diseases.
综述肌肉减少症与骨关节炎（OA）相关性的研究进展。
广泛查阅近年来国内外关于肌肉减少症和OA的基础及临床研究。从流行病学现状、危险因素、发病机制、临床治疗以及对关节置换术的影响五个方面分析并总结肌肉减少症与OA的相关性。
肌肉减少症和OA是老年人的常见疾病，患病率高，且会增加彼此的患病风险。它们有一系列共同的危险因素，在发病机制和临床治疗方面呈现负向交互和影响，从而相互参与对方的疾病进程并降低治疗效果。临床研究表明，肌肉减少症可通过多种方式影响全关节置换术后的康复效果并增加术后并发症风险。
目前的研究结果表明，肌肉减少症和OA相关，且在上述5个方面可相互影响，但仍需要更多研究进一步阐明它们之间的关系，以便为这两种疾病的认识、预防、诊断及治疗提供更多理论依据。
