Harima Y, Maekawa T, Miyauchi Y, Tsutsui T, Sakabe T, Koshiro A
Department of Pharmacy, Yamaguchi University Hospital, Japan.
Intensive Care Med. 1987;13(5):361-2. doi: 10.1007/BF00255796.
Overdosage intoxication of sulindac, tiaramide and diclofenac caused excitability of central nervous system, followed by unconsciousness. The case was treated with ordinary therapies and direct hemoperfusion (DHP). Serum concentrations of these drugs and their metabolites were correlated well with the clinical symptoms. DHP may be effective to eliminate these drugs and their metabolites.
舒林酸、噻洛芬酸和双氯芬酸过量中毒会导致中枢神经系统兴奋，随后出现昏迷。该病例采用常规疗法和直接血液灌流（DHP）进行治疗。这些药物及其代谢物的血清浓度与临床症状密切相关。直接血液灌流可能对清除这些药物及其代谢物有效。
