Kulling P E, Backman E A, Skagius A S, Beckman E A
Swedish Poison Information Centre, Karolinska Hospital, Stockholm.
J Toxicol Clin Toxicol. 1995;33(2):173-7. doi: 10.3109/15563659509000469.
Acute renal dysfunction has been described as a feature of acute overdoses of the nonsteroidal anti-inflammatory drugs benoxaprofen, fenoprofen, ibuprofen, mefenamic acid, piroxicam, suprofen, and zomepirac. The cases reported here include renal impairment after acute overdoses of another three nonsteroidal anti-inflammatory drugs: diclofenac (one case), naproxen (two cases), and sulindac (five cases). The eight patients presented with lumbar pain and oliguria and had protein and erythrocytes in the urine. Serum creatinine was increased to a maximum of 190-932 mumol/L. Renal impairment was generally transient but in one case was treated by hemodialysis and one by continuous arterio-venous hemofiltration dialysis. In all cases of significant acute overdose of nonsteroidal anti-inflammatory drugs, the risk of acute renal dysfunction must be considered.
急性肾功能障碍已被描述为非甾体抗炎药（如贝诺洛芬、非诺洛芬、布洛芬、甲芬那酸、吡罗昔康、舒洛芬和佐美酸）急性过量服用的一个特征。本文报道的病例包括另外三种非甾体抗炎药急性过量服用后的肾功能损害：双氯芬酸（1例）、萘普生（2例）和舒林酸（5例）。这8例患者均出现腰痛和少尿，尿液中有蛋白质和红细胞。血清肌酐最高升至190 - 932μmol/L。肾功能损害一般为短暂性，但有1例接受了血液透析治疗，1例接受了连续性动静脉血液滤过透析治疗。在所有非甾体抗炎药严重急性过量服用的病例中，必须考虑急性肾功能障碍的风险。
