Musson D G, Vincek W C, Constanzer M L, Detty T E
J Pharm Sci. 1984 Sep;73(9):1270-3. doi: 10.1002/jps.2600730921.
A high-performance liquid chromatographic method using a linear elution gradient has been developed for the analysis of sulindac, sulindac sulfone, and sulindac sulfide in plasma, urine, bile, and gastric fluid. The methodology uses reverse-phase, radial compression chromatography with gradient elution, and UV detection. Sulindac and its metabolites in plasma can be quantitated at 0.25 microgram/mL with a mean CV of 6.0 +/- 2.9%; urine, bile, and gastric fluid (0.5 microgram/mL) yield a mean CV of 5.5 +/- 1.9%.
已开发出一种采用线性洗脱梯度的高效液相色谱法，用于分析血浆、尿液、胆汁和胃液中的舒林酸、舒林酸砜和舒林酸硫化物。该方法采用反相径向压缩色谱法进行梯度洗脱，并通过紫外检测。血浆中的舒林酸及其代谢物在浓度为0.25微克/毫升时可进行定量分析，平均变异系数为6.0±2.9%；尿液、胆汁和胃液（0.5微克/毫升）的平均变异系数为5.5±1.9%。
