Ioannou Petros, Kofteridis Diamantis P, Alexakis Konstantinos, Koutserimpas Christos, Papakitsou Ioanna, Maraki Sofia, Samonis George
COVID-19 Department, University Hospital of Heraklion, 71500 Heraklion, Greece.
Department of Orthopaedics and Traumatology, "251" Hellenic Air Force General Hospital of Athens, 11525 Athens, Greece.
Diagnostics (Basel). 2022 Dec 6;12(12):3065. doi: 10.3390/diagnostics12123065.
Coronavirus disease 2019 (COVID-19), a disease characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has so far led to hundreds of millions of infections and millions of deaths. Fungal infections are known to complicate COVID-19 patients and are associated with significant morbidity and mortality. The aim of this study was to assess the incidence of positive cultures for spp. among patients hospitalized with COVID-19, describe their characteristics and identify factors associated with overall mortality in this patient population. Hospitalized COVID-19 patients with spp. isolation were retrospectively assessed and their clinical, laboratory and microbiological characteristics were assessed and evaluated. In total, 69 patients with COVID-19 had a positive culture for spp., representing a rate of 4.5% among all hospitalized COVID-19 patients. Their median age was 78 years (IQR 67-85 years) and 44.9% were male. Hospitalized patients with COVID-19 and spp. isolation who died were older, were more likely to have a diagnosis of dementia, and had higher Charlson comorbidity index, higher score and higher 4C score. score was identified with a multivariate logistic regression analysis model to be independently associated with mortality. The most commonly identified species was , followed by and and the most common source was the urine, even though in most cases the positive culture was not associated with a true infection. Thus, score may be used in COVID-19 patients with isolation of spp. from different body specimens for mortality risk stratification.
2019冠状病毒病（COVID-19）是一种由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的疾病，迄今为止已导致数亿人感染和数百万人死亡。已知真菌感染会使COVID-19患者病情复杂化，并与显著的发病率和死亡率相关。本研究的目的是评估COVID-19住院患者中[具体真菌种类]培养阳性的发生率，描述其特征，并确定该患者群体中与总体死亡率相关的因素。对COVID-19住院且有[具体真菌种类]分离的患者进行回顾性评估，并对其临床、实验室和微生物学特征进行评估和评价。共有69例COVID-19患者[具体真菌种类]培养呈阳性，占所有住院COVID-19患者的4.5%。他们的中位年龄为78岁（四分位间距67 - 85岁），44.9%为男性。COVID-19住院且有[具体真菌种类]分离的死亡患者年龄更大，更有可能被诊断为痴呆，且Charlson合并症指数更高、[具体评分]更高和4C评分更高。通过多因素逻辑回归分析模型确定[具体评分]与死亡率独立相关。最常鉴定出的[真菌种类]是[具体名称1]，其次是[具体名称2]和[具体名称3]，最常见的来源是尿液，尽管在大多数情况下培养阳性与真正的感染无关。因此，[具体评分]可用于对从不同身体标本中分离出[具体真菌种类]的COVID-19患者进行死亡风险分层。
