Rogalska Marta, Antkowiak Lukasz, Kasperczuk Anna, Scierski Wojciech
Faculty of Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.
Department of Pediatric Neurosurgery, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.
J Clin Med. 2022 Dec 12;11(24):7360. doi: 10.3390/jcm11247360.
Recently, contrast-enhanced ultrasound (CEUS) has become a promising tool in distinguishing benign from malignant parotid gland tumors. However, its usefulness in differentiating various benign parotid tumors has not been determined so far. This study aimed to systematically review the literature to determine the utility of CEUS in the preoperative differentiation between pleomorphic adenomas (PAs) and Warthin's tumors (WTs) of the parotid gland. PubMed, Embase, and Cochrane were searched for English-language articles published until 21 July 2022. Fifteen studies were included. On CEUS examination, a significantly greater percentage of PAs displayed heterogeneous enhancement texture compared to WTs. Contrarily, the enhanced lesion size, the enhancement margin, and the presence of the enhancement rim did not differ significantly between the entities. Significantly longer normalized mean transit time (nMTT) and time to peak (TTP) were observed in PAs. Contrarily, the mean values of area under the curve (AUC) and time from peak to one half (TPH) were significantly higher for WTs. Due to the considerable overlap among the qualitative CEUS characteristics of PAs and WTs, the reproducible, investigator-independent quantitative CEUS measurements have a greater potential to distinguish PAs from WTs, which might influence the selection of an appropriate management strategy.
最近，超声造影（CEUS）已成为鉴别腮腺良恶性肿瘤的一种有前景的工具。然而，其在鉴别各种腮腺良性肿瘤方面的效用迄今尚未确定。本研究旨在系统回顾文献，以确定CEUS在腮腺多形性腺瘤（PAs）和沃辛瘤（WTs）术前鉴别诊断中的效用。检索了PubMed、Embase和Cochrane数据库，查找截至2022年7月21日发表的英文文章。纳入了15项研究。在CEUS检查中，与WTs相比，PAs表现出不均匀强化质地的比例显著更高。相反，实体之间强化病变大小、强化边缘和强化环的存在情况无显著差异。在PAs中观察到标准化平均通过时间（nMTT）和达峰时间（TTP）明显更长。相反，WTs的曲线下面积（AUC）和从峰值到一半的时间（TPH）的平均值显著更高。由于PAs和WTs的CEUS定性特征之间存在相当大的重叠，可重复的、与研究者无关的CEUS定量测量在区分PAs和WTs方面具有更大的潜力，这可能会影响合适治疗策略的选择。
