Zhai Pengfei, Chai Yanfei, Lu Ling
Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Center for Hygienic Analysis and Detection, Nanjing Medical University, Nanjing 211166, China.
Microorganisms. 2022 Dec 14;10(12):2469. doi: 10.3390/microorganisms10122469.
is an opportunistic airborne fungus that causes severe invasive aspergillosis in immunocompromised patients. Zinc is an essential micronutrient for the growth of and even for all microorganisms. An increasing number of studies have reported that fungal zinc acquisition ability plays a key role in fungal survival in hosts with an extremely zinc-limited microenvironment. The ability to fight scarcity and excess of zinc are tightly related to fungal virulence and may be used as new potential targets. Because the regulation of zinc homeostasis is important, a thorough understanding of the functional genes involved in the regulatory network for zinc homeostasis is required for fungal pathogens. The current mini-review summarized potential zinc homeostasis regulators in and classified these regulators according to localization and function, which were identified or predicted based on or deduced from homologs in model yeasts. Future perspectives for zinc homeostasis regulators as potential antifungal targets to treat invasive aspergillosis are also discussed.
是一种机会性空气传播真菌，可在免疫功能低下的患者中引起严重的侵袭性曲霉病。锌是其生长甚至所有微生物生长所必需的微量营养素。越来越多的研究报告称，真菌获取锌的能力在锌极度有限的微环境宿主中真菌的生存中起关键作用。对抗锌缺乏和过量的能力与真菌毒力密切相关，可能被用作新的潜在靶点。由于锌稳态的调节很重要，真菌病原体需要深入了解参与锌稳态调节网络的功能基因。当前的小型综述总结了曲霉中的潜在锌稳态调节因子，并根据定位和功能对这些调节因子进行了分类，这些调节因子是基于曲霉或从模式酵母中的同源物推导出来而鉴定或预测的。还讨论了锌稳态调节因子作为治疗侵袭性曲霉病的潜在抗真菌靶点的未来前景。
