Department of Oral Medicine, Dental and Life Science Institute, Pusan National University, Yangsan, Republic of Korea.
Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea.
Clin Exp Dent Res. 2023 Feb;9(1):219-229. doi: 10.1002/cre2.705. Epub 2022 Dec 23.
Although several studies have investigated effective treatments for masticatory muscle pain (MMP), no unified conclusion has been drawn regarding the effectiveness of these treatments.
This study aimed to define quantitative indicators for predicting the outcome of MMP treatment.
In total, patients aged 20-70 years were recruited and divided into the MMP (n = 24) and control (n = 36) groups, based on the presence of MMP according to the Diagnostic Criteria for Temporomandibular Disorders. At pretreatment, the MMP group was assessed using quantitative indicators such as subjective pain levels, pain duration, graded chronic pain scale (GCPS), and perceived stress scale (PSS). Salivary alpha-amylase (sAA) and interleukin-6 (IL-6) levels were analyzed. The masticatory muscle palpation score and the range of mouth opening were measured. At posttreatment, subjective pain levels, mouth opening, and treatment/medication duration were examined. The PSS and sAA levels were assessed in the control group.
sAA levels in the MMP group were significantly higher than those in the control group (p < .05). The masseter muscle palpation score (MPS) showed a positive correlation with IL-6 levels (ρ = 0.503, p < .05) and a negative correlation with nonsteroidal anti-inflammatory drug (NSAID) treatment period (ρ = -0.462, p < .05). The temporalis muscle palpation score (TPS) was positively correlated with pain duration and GCPS grade (ρ = 0.483, p < .05, and ρ = 0.445, p < .05, respectively).
Treatment with NSAIDs was effective in the MMP group with high MPS and IL-6 levels, but not in the MMP group with high TPS, pain duration, and GCPS grade.
尽管已有多项研究调查了咀嚼肌疼痛（MMP）的有效治疗方法，但这些治疗方法的有效性尚未得出统一结论。
本研究旨在确定 MMP 治疗结果的定量指标。
根据《颞下颌关节紊乱诊断标准》，共招募了 20-70 岁的患者，分为 MMP（n=24）和对照组（n=36）。在治疗前，使用主观疼痛水平、疼痛持续时间、分级慢性疼痛量表（GCPS）和感知压力量表（PSS）等定量指标评估 MMP 组。分析唾液α-淀粉酶（sAA）和白细胞介素-6（IL-6）水平。测量咀嚼肌触诊评分和张口范围。治疗后，检查主观疼痛水平、张口度和治疗/用药持续时间。评估对照组的 PSS 和 sAA 水平。
MMP 组 sAA 水平明显高于对照组（p<.05）。咀嚼肌触诊评分（MPS）与 IL-6 水平呈正相关（ρ=0.503，p<.05），与非甾体抗炎药（NSAID）治疗期呈负相关（ρ=-0.462，p<.05）。颞肌触诊评分（TPS）与疼痛持续时间和 GCPS 等级呈正相关（ρ=0.483，p<.05，和 ρ=0.445，p<.05）。
在 MMP 组中，MPS 和 IL-6 水平较高的患者使用 NSAID 治疗有效，但 TPS、疼痛持续时间和 GCPS 等级较高的患者无效。
