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原发性闭角型青光眼患者行白内障手术治疗青光眼的 10 年疗效观察。

Ten-year outcomes of cataract surgery for glaucoma management in patients with primary angle-closure disease.

机构信息

Department of Ophthalmology, Kobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe-shi, Hyogo, 650-0047, Japan.

Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.

出版信息

Jpn J Ophthalmol. 2023 Mar;67(2):129-137. doi: 10.1007/s10384-022-00971-8. Epub 2022 Dec 24.

Abstract

PURPOSE

To investigate the long-term outcomes of cataract surgery for glaucoma management in patients with primary angle-closure disease (PACD).

STUDY DESIGN

Retrospective case series.

METHODS

We reviewed the medical records of 87 eyes of 87 patients with PACD who underwent uncomplicated cataract surgery alone at the Kobe City Medical Center General Hospital. Only patients with a minimum follow-up of 10 years were included. The patients were divided into PACD spectrum categories: primary angle-closure glaucoma (PACG), primary-angle closure (PAC), and primary angle-closure suspect (PACS). The treatment outcomes were compared among the 3 groups. Intraocular pressure (IOP), number of glaucoma eye drops, requirement of additional glaucoma treatment, visual field progression, and progression to glaucoma during the follow-up period were evaluated.

RESULTS

Among the 87 patients, 39 had PACG; 26, PAC; and 22, PACS. Ten years after surgery, the IOP had significantly decreased from baseline in all 3 groups. The rate of requirement of additional glaucoma treatment during the follow-up period was significantly higher in the PACG group than in the other groups. Almost half of the patients with PACG required additional glaucoma treatment; of those patients, six (15.4%) underwent glaucoma surgery. Three patients (11.5%) with PAC required additional glaucoma medication. Visual field progression was observed in 28.1% of the patients with PACG. In 1 patient with PAC, the condition progressed to PACG, but there was no such progression in any of the patients with PACS.

CONCLUSIONS

We confirmed that cataract surgery had a long-term (> 10 years) effect on IOP reduction in eyes with PACD. Early intervention with cataract surgery may be preferable for glaucoma management in patients with PACD.

摘要

目的

探讨原发性闭角型青光眼(PACG)患者行白内障手术治疗青光眼的长期效果。

研究设计

回顾性病例系列研究。

方法

我们回顾了在神户市医疗中心综合医院接受单纯白内障手术治疗的 87 例 87 只眼 PACG 患者的病历。仅纳入随访时间≥10 年的患者。根据 PACG 谱分类,将患者分为原发性闭角型青光眼(PACG)、原发性房角关闭(PAC)和原发性房角关闭可疑(PACS)3 组。比较 3 组患者的治疗效果。评估各组患者的眼压(IOP)、青光眼滴眼液使用数量、是否需要附加青光眼治疗、视野进展情况及随访期间青光眼进展情况。

结果

87 例患者中,PACG 39 例,PAC 26 例,PACS 22 例。术后 10 年,3 组患者的 IOP 均较基线显著降低。PACG 组患者在随访期间需要附加青光眼治疗的比例显著高于其他两组。近一半的 PACG 患者需要附加青光眼治疗;其中 6 例(15.4%)患者接受了青光眼手术。3 例(11.5%)PAC 患者需要附加青光眼药物治疗。PACG 组中有 28.1%的患者出现视野进展。1 例 PAC 患者病情进展为 PACG,但 PACS 组患者无一例出现这种进展。

结论

我们证实白内障手术对 PACG 患者的眼压降低具有长期(>10 年)效果。对于 PACG 患者,早期行白内障手术干预可能更有利于青光眼的治疗。

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