Center for Inflammation Research-VIB, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
EMBO Mol Med. 2023 Feb 8;15(2):e16427. doi: 10.15252/emmm.202216427. Epub 2022 Dec 27.
Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by providing niche factors to the intestinal stem cell compartment, regulating the composition of the microbiome through the production and secretion of antimicrobial peptides, performing phagocytosis and efferocytosis, taking up heavy metals, and preserving barrier integrity. Disturbances in one or more of these functions can lead to intestinal as well as systemic inflammatory and infectious diseases. This review discusses the multiple functions of Paneth cells, and the mechanisms and consequences of Paneth cell dysfunction. It also provides an overview of the tools available for studying Paneth cells.
潘氏细胞是位于小肠的利伯屈恩隐窝中的多功能分泌细胞。在正常情况下，它们通过维持体内平衡作为肠道健康的基石发挥作用。它们通过向肠干细胞隔室提供生态位因子、通过产生和分泌抗菌肽来调节微生物组的组成、进行吞噬作用和细胞凋亡、摄取重金属以及保持屏障完整性来发挥此功能。这些功能中的一个或多个功能的紊乱可导致肠道以及全身炎症和感染性疾病。本综述讨论了潘氏细胞的多种功能，以及潘氏细胞功能障碍的机制和后果。它还概述了用于研究潘氏细胞的工具。
