1201 Inhibits Intestinal Infection of subsp. Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet.

Typhimurium is widely distributed in food. It can colonise the gastrointestinal tract after ingestion, causing lamina propria edema, inflammatory cell infiltration, and mucosal epithelial decomposition. A high-fat diet (HFD) can induce an inflammatory response, but whether HFD can increase the infection level of Typhimurium is unknown. We established a model of subsp. serovar Typhimurium strain ATCC 13311 ATCC 13311 infection in healthy adult mice with a maintenance diet (MD) or HFD to explore the effect of 1201 intervention on Typhimurium ATCC 13311 colonization and its protective effects on mice. HFD exacerbated the infection of Typhimurium ATCC 13311, while the intervention of 1201 effectively mitigated this process. 1201 can reduce the colonies of ATCC 13311 in the intestines and tissues; and reduce intestinal inflammation by down-regulating the level of TLR4/NF-κB pathway related proteins in serum and the expression of related inflammatory factors in the colon and jejunum. Since 1201 can inhibit the colonization of Typhimurium ATCC 13311 and relieve inflammation in HFD, current research may support the use of 1201 to prevent Typhimurium infection.