Shepard C C, van Landingham R, Walker L L
Infect Immun. 1980 Sep;29(3):1034-9. doi: 10.1128/iai.29.3.1034-1039.1980.
All mycobacteria species share some antigens, so there may be cultivable mycobacterial cultures that can provide vaccine protection against leprosy. Vaccine protection against Mycobacterium leprae infections in mice has been demonstrated for M. leprae itself, as living or heat-killed suspensions, and for Mycobacterium bovis (BCG), as living suspensions. Results are reported here with 17 other cultures. The mycobacterial suspensions were injected intradermally, and the mice were challenged in the footpad with infectious suspensions of M. leprae. In two experiments the mice were also challenged by footpad injections of 10(7) heat-killed M. leprae so the footpad enlargment could be measured. That some mycobacterial suspensions were immunogenic for some of their own antigens was suggested by reactions at the vaccine site and enlargement of the regional lymph nodes. Some mycobacterial suspensions also stimulated footpad enlargement on challenge by homologous suspensions or by challenge with M. leprae suspensions. Consistent protection against infectious challenge with M. leprae was observed only with BCG and M. leprae, however.
所有分枝杆菌属物种都有一些共同抗原，因此可能存在可培养的分枝杆菌培养物，能够提供针对麻风病的疫苗保护。对于麻风分枝杆菌本身（作为活的或热灭活的悬液）以及牛分枝杆菌（卡介苗，作为活悬液），已经证明了其对小鼠麻风分枝杆菌感染具有疫苗保护作用。本文报告了对其他17种培养物的研究结果。将分枝杆菌悬液皮内注射，然后用麻风分枝杆菌感染性悬液对小鼠足垫进行攻击。在两项实验中，还用10⁷个热灭活的麻风分枝杆菌对小鼠足垫进行注射攻击，以便能够测量足垫肿胀情况。疫苗接种部位的反应以及局部淋巴结肿大表明，一些分枝杆菌悬液对其自身的某些抗原具有免疫原性。一些分枝杆菌悬液在用同源悬液攻击或用麻风分枝杆菌悬液攻击时，也会刺激足垫肿胀。然而，仅观察到卡介苗和麻风分枝杆菌对麻风分枝杆菌感染性攻击具有持续的保护作用。
