Mugalbayeva Madina Amanzholovna, Mirzakulova Ulmeken Rakhimovna, Zaitenova Gulbaran Baigazinovna, Uglanov Zharkinbek Shertajuly
Department of Surgical Dentistry, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Department of Maxillofacial Surgery for Adults and Pediatrics, Kazakh-Russian Medical University, Almaty, Kazakhstan.
Contemp Clin Dent. 2024 Apr-Jun;15(2):84-88. doi: 10.4103/ccd.ccd_544_23. Epub 2024 Jul 10.
A surgical removal of the lower third molars can lead to a number of complications, and bone restoration typically takes a large amount of time. The aim of the study was to investigate the effect of the combination of beta-tricalcium phosphate (β-TCP), plasmogel, and platelet-rich plasma on postsurgery bone tissue restoration by means of X-ray.
A total of 200 patients who underwent a complicated removal of the lower third molars were nonrandomly assigned to the experimental (EXP, = 100) or control (CTR, = 100) group. In the EXP group patients, sockets were filled with a combination of β-TCP, plasmogel, and platelet-rich plasma. In the CTR group, sockets were not treated. X-ray examinations were performed 3, 6, and 9 months (T1, T2, and T3) postsurgery to define bone quality on the Misch scale. The Mann-Whitney -test was used for between-group comparison.
Aside from the overconsumption of sugars (more frequently in CTR) and marginally significant sex ratio difference (more females in CTR), the groups were equivalent. Although both groups improved on bone density with time, the EXP group demonstrated greater restoration at T1 ( = 3431, < 0.001), T2 ( = 3190, < 0.001), and T3 ( = 3505, < 0.001) related to a greater percentage of D2 (dense thick porous cortical bone on the ridge and a coarse underlying trabecular bone).
A combination of β-TCP, plasmogel, and platelet-rich plasma, compared to no treatment, facilitates bone tissue restoration after complicated surgical removal of the lower third molars.
下颌第三磨牙的外科手术拔除可能导致多种并发症，并且骨修复通常需要大量时间。本研究的目的是通过X射线研究β-磷酸三钙（β-TCP）、血浆凝胶和富血小板血浆联合应用对术后骨组织修复的影响。
总共200例接受复杂下颌第三磨牙拔除术的患者被非随机分配到试验组（EXP，n = 100）或对照组（CTR，n = 100）。试验组患者的牙槽窝用β-TCP、血浆凝胶和富血小板血浆联合填充。对照组患者的牙槽窝未进行处理。术后3、6和9个月（T1、T2和T3）进行X射线检查，以根据米施量表确定骨质量。组间比较采用曼-惠特尼U检验。
除了糖分摄入过多（对照组更常见）和性别比例存在轻微显著差异（对照组女性更多）外，两组相当。尽管两组的骨密度均随时间改善，但试验组在T1（U = 3431，P < 0.001）、T2（U = 3190，P < 0.001）和T3（U = 3505，P < 0.001）时显示出更大的修复，这与更高比例的D2（牙槽嵴上致密的厚多孔皮质骨和粗大的下方小梁骨）有关。
与不进行治疗相比，β-TCP、血浆凝胶和富血小板血浆联合应用有助于复杂外科手术拔除下颌第三磨牙后的骨组织修复。
