Food Safety & Hygiene Division, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Science and Nutrition Group (FSANG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Adv Colloid Interface Sci. 2023 Jan;311:102827. doi: 10.1016/j.cis.2022.102827. Epub 2022 Dec 20.
Electrospinning (ES) is one of the most investigated processes for the convenient, adaptive, and scalable manufacturing of nano/micro/macro-fibers. With this technique, virgin and composite fibers may be made in different designs using a wide range of polymers (both natural and synthetic). Electrospun protein fibers (EPF) shave desirable capabilities such as biocompatibility, low toxicity, degradability, and solvolysis. However, issues with the proteins' processibility have limited their widespread utilization. This paper gives an overview of the features of protein-based biomaterials, which are already being employed and has the potential to be exploited for ES. State-of-the-art examples showcasing the usefulness of EPFs in the food and biomedical industries, including tissue engineering, wound dressings, and drug delivery, provided in the applications. The EPFs' future perspective and the challenge they pose are presented at the end. It is believed that protein and biopolymeric nanofibers will soon be manufactured on an industrial scale owing to the limitations of employing synthetic materials, as well as enormous potential of nanofibers in other fields, such as active food packaging, regenerative medicine, drug delivery, cosmetic, and filtration.
静电纺丝（ES）是最受关注的过程之一，可方便、适应性强且可扩展地制造纳米/微米/宏观纤维。通过该技术，可以使用广泛的聚合物（天然和合成的）以不同的设计制造原始纤维和复合纤维。静电纺丝蛋白质纤维（EPF）具有生物相容性、低毒性、可降解性和溶剂分解性等理想特性。然而，由于蛋白质的加工问题，限制了其广泛应用。本文概述了已经用于静电纺丝的基于蛋白质的生物材料的特性，以及具有潜在应用前景的特性。在应用方面，提供了静电纺丝蛋白质纤维在食品和生物医学领域（包括组织工程、伤口敷料和药物输送）的有用性的最新实例。介绍了 EPFs 的未来展望和面临的挑战。由于使用合成材料的局限性以及纳米纤维在其他领域（如活性食品包装、再生医学、药物输送、化妆品和过滤）的巨大潜力，相信蛋白质和生物聚合物纳米纤维将很快实现工业化生产。
