Al-Khazali Haidar Muhsen, Al-Khazali Sarra, Iljazi Afrim, Christensen Rune Häckert, Ashina Sait, Lipton Richard Bruce, Amin Faisal Mohammad, Ashina Håkan
Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
BIDMC Comprehensive Headache Center, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Cephalalgia. 2023 Jan;43(1):3331024221131343. doi: 10.1177/03331024221131343.
To estimate the relative frequencies of hemicrania continua and its clinical features in adult patients who were evaluated for headache in a clinic-based setting.
PubMed and Embase were searched for observational, clinic-based studies published between 1 January 2004 and 1 February 2022, that reported on the relative frequencies of hemicrania continua and its clinical features. Two independent investigators (HMA and SA-K) screened titles, abstracts, and full text-articles. A random-effects meta-analysis was conducted to estimate pooled relative frequencies of hemicrania continua and its clinical features across clinic-based studies.
Eleven clinic-based studies were deemed eligible for inclusion. Of these, eight studies reported on the relative frequency of hemicrania continua among adult patients (n = 9854) who were evaluated for headache in a tertiary care unit. The pooled relative frequency of hemicrania continua was found to be 1.8% (95% CI; 1.0-3.3). Considerable heterogeneity was noted across studies (I = 89.8%). The three most common symptoms associated with hemicrania continua were lacrimation (72.3%), conjunctival injection (69.8%), and restlessness/agitation (60.2%).
The findings of this meta-analysis suggest that there is limited epidemiologic data on the relative frequencies of hemicrania continua and its clinical features. Standardized data acquisition and reporting are needed to estimate prevalence rates more accurately and to better understand epidemiologic patterns. This, in turn, should increase awareness of the impact that hemicrania continua has in clinical practice.
评估在以门诊为基础的环境中接受头痛评估的成年患者中连续性偏头痛的相对频率及其临床特征。
检索PubMed和Embase数据库，查找2004年1月1日至2022年2月1日期间发表的基于门诊的观察性研究，这些研究报告了连续性偏头痛的相对频率及其临床特征。两名独立研究人员（HMA和SA-K）筛选标题、摘要和全文文章。进行随机效应荟萃分析，以估计基于门诊研究的连续性偏头痛及其临床特征的合并相对频率。
11项基于门诊的研究被认为符合纳入标准。其中，8项研究报告了在三级医疗单位接受头痛评估的成年患者（n = 9854）中连续性偏头痛的相对频率。连续性偏头痛的合并相对频率为1.8%（95%CI；1.0 - 3.3）。各研究间存在相当大的异质性（I = 89.8%）。与连续性偏头痛相关的三个最常见症状是流泪（72.3%）、结膜充血（69.8%）和烦躁不安/激动（60.2%）。
这项荟萃分析的结果表明，关于连续性偏头痛的相对频率及其临床特征的流行病学数据有限。需要标准化的数据采集和报告，以更准确地估计患病率，并更好地了解流行病学模式。这反过来应该提高对连续性偏头痛在临床实践中影响的认识。
