Sethi P, Banerjee A K, Jones D M, Eldridge J, Hollanders D
University Hospital of South Manchester, UK.
Postgrad Med J. 1987 Jul;63(741):543-5. doi: 10.1136/pgmj.63.741.543.
Gastric biopsy specimens were obtained from 83 patients without peptic ulcer disease and analysed histologically. Culture and serological studies were done on the last 64 patients. The patients were divided into two age groups (young and old groups.) In 34 patients with chronic superficial gastritis, gastric campylobacter-like organisms (GLCO) were identified histologically in 91% and grown on culture in 88%: antibody to GCLO was detected in 81%. No age-related difference in the prevalence of the organism was demonstrated. In the 23 patients with atrophic gastritis (all elderly), presence of the organisms appeared to be related to the presence of an inflammatory cell infiltrate into the gastric mucosa. These figures for the prevalence of the organism in this selected group of patients are similar to those reported in previous studies of unselected patients which included those with peptic ulcer. This suggests that GCLO is unlikely to be causally related to peptic ulcer.
从83例无消化性溃疡疾病的患者身上获取胃活检标本，并进行组织学分析。对最后64例患者进行了培养和血清学研究。患者被分为两个年龄组（年轻组和老年组）。在34例慢性浅表性胃炎患者中，组织学鉴定出胃弯曲杆菌样微生物（GLCO）的比例为91%，培养生长的比例为88%：检测到抗GCLO抗体的比例为81%。未发现该微生物的患病率与年龄相关差异。在23例萎缩性胃炎患者（均为老年人）中，该微生物的存在似乎与胃黏膜炎症细胞浸润的存在有关。在这组选定患者中该微生物的患病率数据与先前对未选定患者（包括消化性溃疡患者）的研究报告相似。这表明GCLO不太可能与消化性溃疡存在因果关系。
