Kermer Pawel, Abdalla Yasser, Klein Guido, Lüers Claus
Nordwest-Krankenhaus Sanderbusch, Friesland Kliniken gGmbH, Sande, Germany.
University Medical Center Göttingen, Germany.
Vaccine X. 2023 Apr;13:100257. doi: 10.1016/j.jvacx.2022.100257. Epub 2022 Dec 28.
Vaccination is considered the best measure to overcome the Sars-Cov2 pandemic. However, changing national recommendations on sequence and time frame necessitate the collection of real-word data on adverse events of Sars-CoV2 vaccination protocols outside of pivotal trials. We report results from a survey on the adverse events and the operational consequences of a Sars-CoV2 vaccination campaign with partly mixed vaccination protocol as well as booster vaccination. While the spectrum of adverse effects in our cohort appeared to be similar to pivotal studies, there were substantial differences in both frequency and distribution with only 3 out of 10 participants staying symptom-free. In over 26% of vaccinees symptoms were so severe, that they stayed at home with mean days on sick leave being 1.5 per person using mixed vaccination protocol. Being aware, that these results might partially be attributable to nocebo effects they are of importance for future vaccination campaigns.
接种疫苗被认为是战胜新冠疫情的最佳措施。然而，国家关于接种顺序和时间框架的建议不断变化，这就需要收集关键试验之外的新冠疫苗接种方案不良事件的真实数据。我们报告了一项关于新冠疫苗接种活动不良事件及操作后果的调查结果，该接种活动采用了部分混合接种方案以及加强接种。虽然我们队列中的不良反应谱似乎与关键研究相似，但在频率和分布上存在显著差异，10名参与者中只有3人没有症状。超过26%的接种者症状严重，以至于他们居家休息，采用混合接种方案的接种者平均每人病假天数为1.5天。尽管意识到这些结果可能部分归因于反安慰剂效应，但它们对未来的疫苗接种活动具有重要意义。
