Nihon University School of Medicine, Tokyo, Japan.
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
J Infect Chemother. 2022 Aug;28(8):1220-1224. doi: 10.1016/j.jiac.2022.05.002. Epub 2022 May 11.
To control the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the promotion of vaccination is important. However, adverse reactions following vaccination remain a concern. To investigate adverse events in the vaccinated Japanese population, we conducted a survey-based study among health care workers, including medical doctors and nurses; other medical staff; and medical university faculty, staff, and students in a single medical school and affiliated hospital in Japan. In addition, we analyzed the association of different adverse events with individual factors (e.g., age, sex) by performing network analysis. While young age and female sex are often considered risk factors for more severe adverse events, the regression models showed neither age nor sex was associated with local injection-site reactions after the second dose in this study. In contrast to local reactions, systemic adverse events were associated with young age and female sex. However, myalgia was unique in that it was not associated with younger age even though the network analysis showed that myalgia was consistently related to arthralgia and belonged to the group of systemic events after both the first and second vaccine doses. Further study is needed to ensure safe and effective vaccination to aid in controlling the COVID-19 pandemic.
为了控制由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）大流行，推广疫苗接种非常重要。然而，疫苗接种后的不良反应仍然令人担忧。为了调查接种疫苗的日本人群中的不良事件，我们在日本的一所医学院及其附属医院中，对包括医生和护士在内的医护人员、其他医务人员以及医科大学的教职员工和学生进行了一项基于调查的研究。此外，我们通过网络分析来研究不同不良事件与个体因素（如年龄、性别）之间的关系。虽然年轻和女性通常被认为是更严重不良反应的风险因素，但本研究中的回归模型显示，年龄和性别均与第二剂疫苗接种后的局部注射部位反应无关。与局部反应不同，全身不良反应与年轻和女性有关。然而，肌痛是个例外，即使网络分析表明肌痛与关节痛始终相关，且属于第一和第二剂疫苗接种后的全身事件组，但肌痛与年龄较小无关。需要进一步研究以确保安全有效的疫苗接种，从而有助于控制 COVID-19 大流行。
