Né Yago Gecy de Sousa, Frazão Deborah Ribeiro, Lopes Géssica de Oliveira, Fagundes Nathália Carolina Fernandes, Souza-Rodrigues Renata Duarte, Paula-Silva Francisco Wanderley Garcia, Maia Lucianne Cople, Lima Rafael Rodrigues
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
School of Dentistry, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, 5528 Edmonton Clinic Health Academy, Edmonton, AB, Canada.
Front Med (Lausanne). 2022 Dec 16;9:990421. doi: 10.3389/fmed.2022.990421. eCollection 2022.
The molar-incisor permineralização (MIH) is a qualitative enamel developing abnormality involving the occlusal and/or incisal third of one or more molars or permanent incisors, caused by systemic factors. Several systemic disorders and environmental factors, such as respiratory diseases, have been reported as probable causes of MIH. Thus, this work aimed to evaluate whether respiratory diseases and MIH are associated. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenGrey, and Google Scholar. The acronym PECO was used, in which the P (population) was humans in permanent dentition stage; (E-exposure) molar-incisor hypomineralization; (C-comparison) reference population and (O - outcome) respiratory diseases. After the search retrieval, the duplicates were removed, and the articles were evaluated by title and abstract; then, the papers were read and thoroughly assessed. After selection, the risk of bias assessment was performed using the Newcastle-Ottawa Scale (NOS) for observational studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to assess the level of evidence. Three thousand six hundred and sixty six were found through the searches. After exclusion by duplicates, title, abstract, and full-reading, 13 articles remained. The articles included in this review evaluated the association of MIH with asthma, tonsilitis, pneumonia, and bronchitis. Most reports showed a low risk of bias. When exploring through GRADE, a very low level of evidence was found. We observed that the included studies showed that children with MIH had more respiratory diseases than the group that did not have MIH.
磨牙-切牙矿化不全（MIH）是一种牙釉质发育异常的定性疾病，累及一个或多个磨牙或恒牙切牙的咬合面和/或切缘三分之一，由全身因素引起。已有报道称，多种全身性疾病和环境因素，如呼吸道疾病，可能是MIH的病因。因此，本研究旨在评估呼吸道疾病与MIH是否相关。检索在电子数据库中进行，包括PubMed、Scopus、Web of Science、Cochrane图书馆、LILACS、OpenGrey和谷歌学术。使用了PECO首字母缩写词，其中P（人群）为恒牙列期的人类；（E-暴露）磨牙-切牙矿化不全；（C-对照）参照人群；（O-结局）呼吸道疾病。检索后，去除重复项，并通过标题和摘要对文章进行评估；然后，阅读并全面评估论文。筛选后，使用纽卡斯尔-渥太华量表（NOS）对观察性研究进行偏倚风险评估。使用推荐分级、评估、制定和评价（GRADE）工具评估证据水平。通过检索共找到3666篇文章。经重复项、标题、摘要和全文阅读排除后，剩余13篇文章。本综述纳入的文章评估了MIH与哮喘、扁桃体炎、肺炎和支气管炎的相关性。大多数报告显示偏倚风险较低。通过GRADE进行探索时，发现证据水平极低。我们观察到，纳入的研究表明，患有MIH的儿童比未患MIH的儿童患呼吸道疾病的更多。
