de Sousa Né Yago Gecy, Frazão Deborah Ribeiro, Bittencourt Leonardo Oliveira, Fagundes Nathalia Carolina Fernandes, Marañón-Vásquez Guido, Crespo-Lopez Maria Elena, Maia Lucianne Cople, Lima Rafael Rodrigues
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, Brazil.
School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Metabolites. 2022 Sep 13;12(9):858. doi: 10.3390/metabo12090858.
This systematic review aimed to assess whether dental caries is associated with oxidative salivary stress. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenGrey, and Google Scholar, without restrictions on the date of publication and language. The acronym PECO was used, in which the participants (P) were children and adolescents exposed (E) to dental caries compared (C) to those without dental caries, with the outcome (O) of modulation of oxidative biochemical parameters. After the search retrieval, the duplicates were removed, and the articles were evaluated by title and abstract, following the inclusion and exclusion criteria. Then, the papers were read and thoroughly assessed. After selection, the risk of bias assessment and qualitative synthesis were performed using the Newcastle-Ottawa Scale (NOS) for observational studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to assess the level of evidence. A total of 5790 studies were found, and 30 articles were considered eligible and were included for the qualitative synthesis and the level of evidence assessment. The studies showed an imbalance of the antioxidant and pro-oxidant parameters in individuals with dental caries, with primarily increases in both total antioxidant capacity and lipid peroxidation. Most articles showed a low risk of bias, having comparability as the main issue. When exploring through GRADE, a very low level of evidence was found. It was possible to observe an association between oxidative stress and dental caries, showing a disbalance of antioxidants and pro-oxidants, but the evidence level was still very low.
本系统评价旨在评估龋齿是否与唾液氧化应激相关。检索在电子数据库中进行，包括PubMed、Scopus、科学网、考克兰图书馆、拉丁美洲和加勒比卫生科学数据库、OpenGrey以及谷歌学术，对出版日期和语言均无限制。使用了首字母缩写词PECO，其中参与者（P）为患龋齿的儿童和青少年，暴露因素（E）为龋齿，对照（C）为无龋齿者，结局（O）为氧化生化参数的调节。检索后，去除重复项，并根据纳入和排除标准通过标题和摘要对文章进行评估。然后，阅读并全面评估这些论文。筛选后，使用纽卡斯尔-渥太华量表（NOS）对观察性研究进行偏倚风险评估和定性合成。使用推荐分级、评估、制定和评价（GRADE）工具评估证据水平。共检索到5790项研究，30篇文章被认为符合纳入标准，并被纳入定性合成和证据水平评估。研究表明，患龋齿个体的抗氧化和促氧化参数失衡，主要表现为总抗氧化能力和脂质过氧化均增加。大多数文章显示偏倚风险较低，主要问题在于可比性。通过GRADE工具进行评估时，发现证据水平非常低。可以观察到氧化应激与龋齿之间存在关联，表明抗氧化剂和促氧化剂失衡，但证据水平仍然很低。
