Columbia University School of Nursing, New York, NY, USA.
Department of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing, Philadelphia, PA, USA; Center for Home Care Policy & Research, VNS Health, New York, NY, USA.
Int J Med Inform. 2023 Feb;170:104978. doi: 10.1016/j.ijmedinf.2022.104978. Epub 2022 Dec 30.
Despite recent calls for home healthcare (HHC) to integrate informatics, the application of machine learning in HHC is relatively unknown. Thus, this study aimed to synthesize and appraise the literature describing the application of machine learning to predict adverse outcomes (e.g., hospitalization, mortality) using electronic health record (EHR) data in the HHC setting. Our secondary aim was to evaluate the comprehensiveness of predictors used in the machine learning algorithms guided by the Biopsychosocial Model.
During March 2022 we conducted a literature search in four databases: PubMed, Embase, CINAHL, and Scopus. Inclusion criteria were 1) describing services provided in the HHC setting, 2) applying machine learning algorithms to predict adverse outcomes, defined as outcomes related to patient deterioration, 3) using EHR data and 4) focusing on the adult population. Predictors were mapped to the Biopsychosocial Model. A risk of bias analysis was conducted using the Prediction Model Risk Of Bias Assessment Tool.
The final sample included 20 studies. Eighteen studies used predictors from standardized assessments integrated in the EHR. The most common outcome of interest was hospitalization (55%), followed by mortality (25%). Psychological predictors were frequently excluded (35%). Tree based algorithms were most frequently applied (75%). Most studies demonstrated high or unclear risk of bias (75%).
Future studies in HHC should consider incorporating machine learning algorithms into clinical decision support systems to identify patients at risk. Based on the Biopsychosocial model, psychological and interpersonal characteristics should be used along with biological characteristics to enhance risk prediction. To facilitate the widespread adoption of machine learning, stakeholders should encourage standardization in the HHC setting.
尽管最近有人呼吁家庭医疗保健(HHC)整合信息学,但机器学习在 HHC 中的应用还相对未知。因此,本研究旨在综合和评价描述使用电子健康记录(EHR)数据在 HHC 环境中应用机器学习预测不良结局(如住院、死亡)的文献。我们的次要目的是评估机器学习算法中使用的预测因子的全面性,这些预测因子由生物心理社会模型指导。
在 2022 年 3 月,我们在四个数据库中进行了文献检索:PubMed、Embase、CINAHL 和 Scopus。纳入标准为:1)描述 HHC 环境中提供的服务,2)应用机器学习算法预测不良结局,定义为与患者恶化相关的结局,3)使用 EHR 数据,4)关注成人人群。预测因子被映射到生物心理社会模型。使用预测模型风险偏倚评估工具进行风险偏倚分析。
最终样本包括 20 项研究。18 项研究使用集成在 EHR 中的标准化评估预测因子。最常见的关注结局是住院(55%),其次是死亡(25%)。心理预测因子经常被排除在外(35%)。基于树的算法最常被应用(75%)。大多数研究显示出高或不明确的偏倚风险(75%)。
未来在 HHC 中的研究应考虑将机器学习算法纳入临床决策支持系统,以识别有风险的患者。基于生物心理社会模型,应将心理和人际关系特征与生物特征一起用于增强风险预测。为了促进机器学习的广泛采用,利益相关者应鼓励 HHC 环境中的标准化。