铁基耦合纳米结构在临床前抗菌治疗中的前景。
Prospects of coupled iron-based nanostructures in preclinical antibacterial therapy.
作者信息
Han Jingjing, Zeng Shuang, Chen Yahui, Li Haidong, Yoon Juyoung
机构信息
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760 Republic of Korea; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
State Key Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024 China.
出版信息
Adv Drug Deliv Rev. 2023 Feb;193:114672. doi: 10.1016/j.addr.2022.114672. Epub 2022 Dec 30.
Bacterial infections can threaten human health. Drug-resistant bacteria have become a challenge because of the excessive use of drugs. We summarize the current metallic antibacterial materials, especially Fe-based materials, for efficiently killing bacteria. The possible antibacterial mechanisms of metallic antibacterial agents are classified into interactions with bacterial proteins, iron metabolism, catalytic activity, and combinations of magnetic, photodynamic, and photothermal effects. This review will inspire the development of novel Fe-based antibacterial agents for clinical settings.
细菌感染会威胁人类健康。由于药物的过度使用，耐药细菌已成为一项挑战。我们总结了当前用于高效杀灭细菌的金属抗菌材料，尤其是铁基材料。金属抗菌剂可能的抗菌机制分为与细菌蛋白质的相互作用、铁代谢、催化活性以及磁、光动力和光热效应的组合。这篇综述将激发新型铁基抗菌剂在临床环境中的开发。
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