• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单细胞基因组方法对阿尔茨海默病的认识。

Insights into Alzheimer's disease from single-cell genomic approaches.

机构信息

Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

出版信息

Nat Neurosci. 2023 Feb;26(2):181-195. doi: 10.1038/s41593-022-01222-2. Epub 2023 Jan 2.

DOI:10.1038/s41593-022-01222-2
PMID:36593328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10155598/
Abstract

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually every major brain cell type. Here, we highlight cell-type-specific molecular perturbations in AD. We discuss how genomic information from single cells expands existing paradigms of AD pathogenesis and highlight new opportunities for therapeutic interventions.

摘要

阿尔茨海默病（AD）是一种与年龄相关的疾病，其病理特征为脑实质中淀粉样斑块和神经原纤维缠结的沉积。单细胞分析显示，阿尔茨海默病痴呆涉及几乎所有主要脑内细胞类型的复杂相互作用。在这里，我们重点介绍 AD 中特定于细胞类型的分子扰动。我们讨论了来自单细胞的基因组信息如何扩展 AD 发病机制的现有范例，并强调了治疗干预的新机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/4fe8066139c7/nihms-1880156-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/59a7a2adebb0/nihms-1880156-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/bde818c841d0/nihms-1880156-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/d04ff4e49a9b/nihms-1880156-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/0632f8dc24c2/nihms-1880156-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/ef4e0d264fc5/nihms-1880156-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/a956f7ff1b10/nihms-1880156-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/4fe8066139c7/nihms-1880156-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/59a7a2adebb0/nihms-1880156-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/bde818c841d0/nihms-1880156-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/d04ff4e49a9b/nihms-1880156-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/0632f8dc24c2/nihms-1880156-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/ef4e0d264fc5/nihms-1880156-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/a956f7ff1b10/nihms-1880156-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f1a/10155598/4fe8066139c7/nihms-1880156-f0007.jpg

相似文献

1
Insights into Alzheimer's disease from single-cell genomic approaches.单细胞基因组方法对阿尔茨海默病的认识。
Nat Neurosci. 2023 Feb;26(2):181-195. doi: 10.1038/s41593-022-01222-2. Epub 2023 Jan 2.
2
The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer's disease.阿尔茨海默病中衰老斑和神经原纤维缠结的分子生物学。
Folia Neuropathol. 2009;47(4):289-99.
3
Protein aggregation in Alzheimer's disease: Aβ and τ and their potential roles in the pathogenesis of AD.阿尔茨海默病中的蛋白质聚集：淀粉样β蛋白和τ蛋白及其在阿尔茨海默病发病机制中的潜在作用。
Acta Neuropathol. 2015 Feb;129(2):163-5. doi: 10.1007/s00401-015-1387-2.
4
Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques.从神经原纤维缠结和老年斑的纤维性病变中厘清阿尔茨海默病。
Neuropathology. 2000 Sep;20 Suppl:S55-60. doi: 10.1046/j.1440-1789.2000.00317.x.
5
Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.剖析非编码RNA在阿尔茨海默病淀粉样蛋白和tau神经病理学积累中的作用。
Mol Neurodegener. 2017 Jul 1;12(1):51. doi: 10.1186/s13024-017-0191-y.
6
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.迈向阿尔茨海默病的综合理论。假说：阿尔茨海默病是由β-淀粉样蛋白在大脑中的积累和细胞毒性引起的。
Ann N Y Acad Sci. 2000;924:17-25. doi: 10.1111/j.1749-6632.2000.tb05554.x.
7
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models.淀粉样蛋白诱导的阿尔茨海默病神经原纤维缠结形成：来自转基因小鼠和组织培养模型的见解。
Int J Dev Neurosci. 2004 Nov;22(7):453-65. doi: 10.1016/j.ijdevneu.2004.07.013.
8
Migration of blood cells to β-amyloid plaques in Alzheimer's disease.血细胞向阿尔茨海默病中β淀粉样斑块的迁移。
Exp Gerontol. 2015 May;65:8-15. doi: 10.1016/j.exger.2015.03.002. Epub 2015 Mar 6.
9
[The pathophysiology of Alzheimer's disease with special reference to "amyloid cascade hypothesis"].[阿尔茨海默病的病理生理学，特别参考“淀粉样蛋白瀑布假说”]
Rinsho Byori. 2013 Nov;61(11):1060-9.
10
Viewpoint: Crosstalks between neurofibrillary tangles and amyloid plaque formation.观点：神经原纤维缠结与淀粉样斑块形成之间的串扰。
Ageing Res Rev. 2013 Jan;12(1):174-81. doi: 10.1016/j.arr.2012.06.002. Epub 2012 Jun 19.

引用本文的文献

1
Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease.阿尔茨海默病中细胞类型特异性主要代谢调节因子的系统表征
Res Sq. 2025 Aug 18:rs.3.rs-7207381. doi: 10.21203/rs.3.rs-7207381/v1.
2
Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.血管性痴呆中伴侣蛋白介导的免疫-蛋白稳态串扰的多组学探索及诊断生物标志物的鉴定
Front Immunol. 2025 Jul 30;16:1615540. doi: 10.3389/fimmu.2025.1615540. eCollection 2025.
3
Cell type-specific master metabolic regulators of Alzheimer's disease.
阿尔茨海默病的细胞类型特异性主要代谢调节因子。
bioRxiv. 2025 Jul 17:2025.07.11.664443. doi: 10.1101/2025.07.11.664443.
4
Lithium deficiency and the onset of Alzheimer's disease.锂缺乏与阿尔茨海默病的发病
Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09335-x.
5
Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer's disease.淀粉样蛋白β破坏hnRNP A2介导的RNA动态变化，从而导致阿尔茨海默病中髓鞘碱性蛋白增加。
Cell Mol Life Sci. 2025 Aug 2;82(1):298. doi: 10.1007/s00018-025-05823-5.
6
Single-Cell Transcriptome Patterns of Transposable Elements in Alzheimer's Disease.阿尔茨海默病中转座元件的单细胞转录组模式
Mol Neurobiol. 2025 Jun 19. doi: 10.1007/s12035-025-05140-9.
7
Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.单核表观基因组失调揭示了与遗传风险相关的神经退行性胶质细胞状态。
bioRxiv. 2025 Jun 4:2025.06.02.657512. doi: 10.1101/2025.06.02.657512.
8
DiSC: a statistical tool for fast differential expression analysis of individual-level single-cell RNA-seq data.DiSC：一种用于个体水平单细胞RNA测序数据快速差异表达分析的统计工具。
Bioinformatics. 2025 Jun 2;41(6). doi: 10.1093/bioinformatics/btaf327.
9
An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration.一种整合的系统生物学方法定义了阿尔茨海默病神经退行性变的机制。
Nat Commun. 2025 May 20;16(1):4441. doi: 10.1038/s41467-025-59654-w.
10
hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation.人诱导多能干细胞来源的神经元重现了对神经退行性疾病相关聚集易感性的亚型特异性细胞内在特性。
Acta Neuropathol Commun. 2025 May 19;13(1):108. doi: 10.1186/s40478-025-02000-4.