Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts & Telecommunications, Nanjing, 210023, P. R. China.
Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, P. R. China.
Chem Commun (Camb). 2023 Jan 19;59(7):912-915. doi: 10.1039/d2cc06367k.
A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.
构建了一种配备针对肿瘤细胞特异性酶（NQO1）的阿霉素衍生前药的矩形 DNA 折纸纳米结构。该纳米系统结合了 DNA 折纸的高前药载量和 NQO1 激活的化疗，为 NQO1 过表达的 MCF-7 细胞提供了对健康 L02 细胞的治疗选择性，为精准癌症治疗提供了一种有力策略。
