一种 DNA 折纸纳米结构，其中嵌入了 NQO1 激活的前药，用于精准药物递送。
A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery.
机构信息
Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts & Telecommunications, Nanjing, 210023, P. R. China.
Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, P. R. China.
出版信息
Chem Commun (Camb). 2023 Jan 19;59(7):912-915. doi: 10.1039/d2cc06367k.
A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.
构建了一种配备针对肿瘤细胞特异性酶（NQO1）的阿霉素衍生前药的矩形 DNA 折纸纳米结构。该纳米系统结合了 DNA 折纸的高前药载量和 NQO1 激活的化疗，为 NQO1 过表达的 MCF-7 细胞提供了对健康 L02 细胞的治疗选择性，为精准癌症治疗提供了一种有力策略。
Zotero 插件