在一位接受异基因造血干细胞移植的女性患者中同时分离到携带 bla 和 bla 的哈夫尼亚 paralvei。
Isolation of Hafnia paralvei co-harbouring bla and bla in a woman who underwent allogeneic hematopoietic stem cell transplantation.
机构信息
Klinik für Innere Medizin II, Abteilung für Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Kastanienstraße 1, 07747, Jena, Germany.
Medizinische Klinik 2, Infektiologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
出版信息
Infection. 2023 Aug;51(4):1161-1164. doi: 10.1007/s15010-022-01976-8. Epub 2023 Jan 3.
Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL.
金属β-内酰胺酶（MBL）对公共健康构成威胁，因为它们极大地限制了β-内酰胺类药物的使用。我们报告了一例异基因造血干细胞移植治疗骨髓增生异常综合征后女性患者尿液和直肠拭子中多药耐药哈夫尼亚 paralvei 菌株的分离。药敏试验显示对复方磺胺甲噁唑、黏菌素、磷霉素和所有β-内酰胺类药物（除头孢地尔外）耐药。全基因组测序显示存在质粒编码的 NDM-1 和 VIM-1 碳青霉烯酶。这一发现强调了对 MBL 进行流行病学监测和新治疗选择的重要性。
Zotero 插件