Department Of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Department of Emergency, 900 Hospital of Joint Logistics Support Force, Dongfang Hospital, Xiamen University, Fuzong Clinical College of Fujian Medical University, Fuzhou, Fujian, China.
BMJ Open. 2022 Dec 8;12(12):e063660. doi: 10.1136/bmjopen-2022-063660.
To explore the prevalence and patterns of multimorbidity in population with different genders and age ranges.
A cross-sectional study.
National Health and Nutrition Examination Surveys database.
12 576 patients.
The prevalence and patterns of multimorbidity.
High cholesterol had the highest prevalence in all population (33.4 (95% CI: 32.0 to 34.9)) and males. In females <65 years, the most prevalent disease was sleep disorder (32.1 (95% CI: 29.6 to 34.5)) while in females ≥65 years, hypertension was the most prevalent disease (63.9 (95% CI: 59.9 to 67.9)). Hypertension and high cholesterol were associated with the highest support (occur together most frequently) in all population regardless of genders. Hypertension displayed the highest betweenness centrality (mediating role in the network) followed by high cholesterol and arthritis in all population. For males aged <65 years, hypertension and high cholesterol presented the highest betweenness centrality. In males ≥65 years, hypertension, high cholesterol and arthritis were the top three diseases of degree centrality (direct association with other conditions). As for females ≥65 years, hypertension showed the highest betweenness centrality followed by high cholesterol and arthritis. The associations of hypertension, arthritis and one other item with high cholesterol presented the highest support in all population. In males, the associations of depression, hypertension with sleep disorders had the highest lift (the chance of co-occurrence of the conditions and significant association). Among females, the associations of depression, arthritis with sleep disorders had the highest lift.
Hypertension and high cholesterol were prevalent in all population, regardless of females and males. Hypertension and high cholesterol, arthritis and hypertension, and diabetes and hypertension were more likely to coexist. The findings of this study might help make plans for the management and primary care of people with one or more diseases.
探讨不同性别和年龄人群中多种疾病的患病率和模式。
横断面研究。
国家健康和营养调查数据库。
12576 名患者。
多种疾病的患病率和模式。
高胆固醇在所有人群（33.4（95%置信区间：32.0 至 34.9））和男性中患病率最高。在<65 岁的女性中，最常见的疾病是睡眠障碍（32.1（95%置信区间：29.6 至 34.5）），而在≥65 岁的女性中，高血压是最常见的疾病（63.9（95%置信区间：59.9 至 67.9））。高血压和高胆固醇与所有人群（无论性别如何）中最高的支持度（最常同时发生）相关。在所有人群中，高血压的介数中心度最高（网络中的中介作用），其次是高胆固醇和关节炎。对于<65 岁的男性，高血压和高胆固醇的介数中心度最高。在≥65 岁的男性中，高血压、高胆固醇和关节炎是度中心度最高的三种疾病（与其他疾病有直接关联）。对于≥65 岁的女性，高血压的介数中心度最高，其次是高胆固醇和关节炎。高血压、关节炎和其他一种疾病与高胆固醇的关联在所有人群中具有最高的支持度。在男性中，抑郁症、高血压与睡眠障碍的关联具有最高的提升度（这些疾病同时发生的几率和显著关联）。在女性中，抑郁症、关节炎与睡眠障碍的关联具有最高的提升度。
高血压和高胆固醇在所有人群中患病率较高，无论男女。高血压和高胆固醇、关节炎和高血压、糖尿病和高血压更有可能同时存在。本研究的结果可能有助于制定管理和初级保健计划，以治疗一种或多种疾病的患者。
