Jayasinghe Maleesha, Caldera Dilushini, Prathiraja Omesh, Jena Rahul, Coffie-Pierre James Anwar, Agyei James, Silva Minollie Suzanne, Kayani Abdul Mueez Alam, Siddiqui Ozair S
Medicine, Nanjing Medical University, Nanjing, CHN.
Internal Medicine, Nanjing Medical University, Nanjing, CHN.
Cureus. 2022 Nov 30;14(11):e32075. doi: 10.7759/cureus.32075. eCollection 2022 Nov.
Angioedema (AE) is a condition that is frequently encountered in the emergency department (ED). It is a rare condition with localized, asymmetrical swelling of the skin and/or mucosa that is frequently nonpruritic and primarily affects locations with loose connective tissue. Physicians must have a thorough understanding of this condition since it can cause fatal airway compromise, which might be the presenting symptom. Histamine-mediated AE is the most common type of AE seen in EDs. However, ED physicians must be on the lookout for the less common bradykinin-mediated types of AE as these do not respond to the same therapy as histamine-mediated AE. Hospitals may lack specialized drugs or protocols, and many ED staff may be unable to identify or treat bradykinin-mediated AE. It is crucial to understand the pathophysiology of the various kinds of AE in order to optimize treatment. The goal of this review paper is to provide an overview of the pathophysiology, clinical manifestations, and treatment options for bradykinin and histamine-induced AE in the ED.
血管性水肿（AE）是急诊科（ED）经常遇到的一种病症。它是一种罕见的病症，表现为皮肤和/或黏膜局部、不对称性肿胀，通常无瘙痒感，主要影响疏松结缔组织所在部位。由于它可能导致致命的气道梗阻，而这可能是首发症状，因此医生必须对这种病症有透彻的了解。组胺介导的AE是急诊科中最常见的AE类型。然而，急诊科医生必须留意较少见的缓激肽介导的AE类型，因为这些类型对组胺介导的AE的治疗方法没有反应。医院可能缺乏专门的药物或方案，许多急诊科工作人员可能无法识别或治疗缓激肽介导的AE。了解各种AE的病理生理学对于优化治疗至关重要。这篇综述文章的目的是概述急诊科中缓激肽和组胺诱导的AE的病理生理学、临床表现及治疗选择。
