Uehara T, Matsubara O, Kasuga T
2nd Department of Pathology, Faculty of Medicine, Tokyo Medical & Dental University, Japan.
Acta Pathol Jpn. 1987 Jul;37(7):1105-14. doi: 10.1111/j.1440-1827.1987.tb00427.x.
Random, nonselected tissue specimens from 99 Japanese-20 cylindrically cut nasal blocks removed during autopsy (A.C., Autopsy Cases) and 79 cases removed during surgery, consisting of 32 chronic sinusitis cases (C.S.) and 47 nasal polyp cases (N.P.)-were examined histopathologically and electronmicroscopically with respect to distribution and frequency of melanocytes in the nasal cavity and paranasal sinus. Malignant melanoma cases were excluded. The overall incidence of positive cases for melanocytes revealed 21.2% (21 of 99 cases), with an incidence ratio of male to female of 0.9:1.0. Melanocytes were found beginning in the under 19 age group with incidence increasing proportionately with age. Peak incidence was in the 50-year age group at 50%. Melanocytes and melanotic cell foci were distributed in the stroma of the propria mucosa beneath the pseudostratified columnar epithelium and focused around the nasal and paranasal glands and sinuses. In 2 of the 21 cases positive for stromal melanocytes, intraepithelial melanocytes with dendritic processes were found. The histogenesis of malignant melanoma arising from the nasal cavity and paranasal sinus are also discussed in this study.
从99例日本患者身上获取的随机、非选择性组织标本——其中20例为尸检（A.C.，尸检病例）时取下的圆柱形鼻组织块，79例为手术时取下的组织块，包括32例慢性鼻窦炎病例（C.S.）和47例鼻息肉病例（N.P.）——针对鼻腔和鼻窦中黑素细胞的分布及出现频率进行了组织病理学和电子显微镜检查。恶性黑色素瘤病例被排除在外。黑素细胞阳性病例的总体发生率为21.2%（99例中的21例），男女发生率之比为0.9:1.0。黑素细胞在19岁以下年龄组开始出现，发生率随年龄成比例增加。发生率峰值出现在50岁年龄组，为50%。黑素细胞和黑素细胞灶分布在假复层柱状上皮下方固有黏膜的基质中，集中在鼻和鼻窦腺周围。在21例基质黑素细胞阳性的病例中，有2例发现了具有树突状突起的上皮内黑素细胞。本研究还讨论了鼻腔和鼻窦恶性黑色素瘤的组织发生。
