Scotto Riccardo, Bagnis Alessandro, Papadia Marina, Cutolo Carlo Alberto, Risso Domenico, Traverso Carlo Enrico
*Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Di.N.O.G.M.I.), Eye Clinic †Department of Health Science (DISSAL), University of Genoa, S. Martino Hospital, Genova, Italy.
J Glaucoma. 2017 Oct;26(10):860-865. doi: 10.1097/IJG.0000000000000745.
To evaluate and compare central corneal thickness (CCT) values measured with anterior segment optical coherence tomography (AS-OCT), noncontact specular microscopy (NCSM), and ultrasound pachymetry (USP).
CCT was measured in 182 healthy eyes without ocular abnormalities other than refractive errors. Three consecutive measurements of CCT by the same examiner were obtained during the same session. The testing sequence of AS-OCT and NCSM was randomly selected. The USP always was performed after the noncontact examinations.
The average CCT measured by AS-OCT, NCSM, and USP were 535.8±35.5, 547.7±38.2, and 537.4±37.5 μm, respectively. The mean differences between modalities were 11.8±14.7 μm (P<0.01) between NCSM and AS-OCT, 10.3±17.7 μm (P<0.01) between NCSM and USP and 1.6±8.6 μm (P=0.02) between USP and AS-OCT.
AS-OCT, NCSM, and USP showed an overall strong agreement in measuring CCT. However, CCT measurements with AS-OCT showed a good correlation to those obtained by USP, NCSM tended to give statistically significant higher CCT readings than either alternative and showed the worse repeatability indices. On the basis of our results, CCT measurement obtained with different instruments cannot be considered directly interchangeable.
评估并比较使用眼前节光学相干断层扫描（AS-OCT）、非接触式角膜内皮显微镜（NCSM）和超声角膜测厚法（USP）测量的中央角膜厚度（CCT）值。
对182只除屈光不正外无眼部异常的健康眼睛进行CCT测量。由同一名检查者在同一时段连续进行三次CCT测量。AS-OCT和NCSM的测试顺序随机选择。USP总是在非接触式检查之后进行。
AS-OCT、NCSM和USP测量的平均CCT分别为535.8±35.5、547.7±38.2和537.4±37.5μm。不同测量方法之间的平均差异为：NCSM与AS-OCT之间为11.8±14.7μm（P<0.01），NCSM与USP之间为10.3±17.7μm（P<0.01），USP与AS-OCT之间为1.6±8.6μm（P=0.02）。
AS-OCT、NCSM和USP在测量CCT方面总体上具有很强的一致性。然而，AS-OCT测量的CCT与USP测量的结果具有良好的相关性，NCSM测得的CCT读数在统计学上往往显著高于其他两种方法，并且重复性指标较差。根据我们的结果，不同仪器获得的CCT测量值不能直接认为是可互换的。
