Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea.
Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Molecules. 2022 Dec 21;28(1):41. doi: 10.3390/molecules28010041.
Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of (APE) against influenza virus infection. Two chlorophyll derivatives, ethyl pheophorbides a and b, isolated as active components of APE, exerted virucidal effects with no evident cytotoxicity. These compounds were effective only under conditions of direct incubation with the virus, and exerted no effects on the influenza A virus (IAV) surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Interestingly, virucidal activities of ethyl pheophorbides a and b were observed against enveloped but not non-enveloped viruses, suggesting that these compounds act by affecting the integrity of the viral membrane and reducing infectivity.
从韩国特有植物的乙醇提取物中筛选出的抗病毒和杀病毒活性表明，（APE）全草的 70%乙醇提取物对流感病毒感染具有抑制活性。两种叶绿素衍生物，乙基脱镁叶绿酸 a 和 b，被分离为 APE 的活性成分，具有杀病毒作用而没有明显的细胞毒性。这些化合物只有在与病毒直接孵育的条件下才有效，并且对甲型流感病毒（IAV）表面糖蛋白血凝素（HA）和神经氨酸酶（NA）没有影响。有趣的是，乙基脱镁叶绿酸 a 和 b 对包膜病毒而非非包膜病毒具有杀病毒活性，表明这些化合物通过影响病毒膜的完整性和降低感染力而起作用。
