Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Torun, Poland.
Molecules. 2022 Dec 28;28(1):247. doi: 10.3390/molecules28010247.
In the times of dynamically developing regenerative medicine, more and more attention is focused on the use of natural polymers. This is due to their high biocompatibility and biodegradability without the production of toxic compounds, which means that they do not hurt humans and the natural environment. Chitosan and its derivatives are polymers made most often from the shells of crustaceans and are biodegradable and biocompatible. Some of them have antibacterial or metal-chelating properties. This review article presents the development of biomaterials based on chitosan and its derivatives used in regenerative medicine, such as a dressing or graft of soft tissues or bones. Various examples of preparations based on chitosan and its derivatives in the form of gels, films, and 3D structures and crosslinking products with another polymer are discussed herein. This article summarizes the latest advances in medicine with the use of biomaterials based on chitosan and its derivatives and provides perspectives on future research activities.
在再生医学迅速发展的时代，人们越来越关注天然聚合物的应用。这是由于它们具有较高的生物相容性和生物降解性，不会产生有毒化合物，这意味着它们不会伤害人类和自然环境。壳聚糖及其衍生物是最常从甲壳类动物的壳中提取的聚合物，具有生物降解性和生物相容性。其中一些具有抗菌或金属螯合特性。本文综述了基于壳聚糖及其衍生物的生物材料在再生医学中的应用，如软组织或骨骼的敷料或移植物。本文讨论了各种基于壳聚糖及其衍生物的制剂，如凝胶、薄膜和 3D 结构，以及与另一种聚合物的交联产物。本文总结了基于壳聚糖及其衍生物的生物材料在医学中的最新进展，并对未来的研究活动提供了展望。
