Laboratory of Fundamental Sciences, University Amar Télidji of Laghouat, Road of Ghardaïa, Laghouat 03000, Algeria.
Nuclear Research Centre of Birine, Ain Oussera, Djelfa 17200, Algeria.
Molecules. 2023 Jan 1;28(1):349. doi: 10.3390/molecules28010349.
in folk medicine is used by Algerian traditional healers for treating a wide variety of diseases and conditions including dyspepsia, digestive problems, peptic ulcers, and, in particular, inflammatory diseases. The present study aimed to assess the phytochemical composition, in vitro antioxidant activity (using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS+, and reducing power methods), enzyme inhibitory activity (towards α-amylase and urease), antibacterial activity, and in vivo anti-inflammatory activity of the unripe fruit extracts of collected from different parts of the Djelfa region of Algeria. According to the findings, various aqueous extracts exhibited significant antioxidant and enzymatic activities in all tests, but showed that they have a weak inhibitory effect against all tested bacterial strains. Twenty-one minerals comprising both macro- and microelements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U, and Zn) were determined using the technique of neutron activation analysis (INAA). The result indicates that the concentration of the mineral element is close to the minimal FAO recommendation. In addition, the result revealed significant anti-inflammatory activities. The data generated can be a valuable source of information for the pharmaceutical industry and medical research. These results suggest that the unripe fruit extracts of have an appropriate potential to be utilized across a wide range of contexts as an agent with multifunctional uses, as well as a natural remedy for other physiological diseases.
在民间医学中，阿尔及利亚传统治疗师使用它来治疗多种疾病和病症，包括消化不良、消化问题、消化性溃疡，特别是炎症性疾病。本研究旨在评估来自阿尔及利亚杰勒法地区不同地区的未成熟果实提取物的植物化学成分、体外抗氧化活性（使用 2,2-二苯基-1-苦基肼（DPPH）、ABTS+和还原力方法）、酶抑制活性（对α-淀粉酶和脲酶）、抗菌活性和体内抗炎活性。研究结果表明，各种水提取物在所有测试中均表现出显著的抗氧化和酶活性，但表明它们对所有测试的细菌菌株均具有较弱的抑制作用。使用中子激活分析（INAA）技术确定了包括宏量和微量元素（Ba、Br、Ca、Cl、Co、Cr、Cs、Eu、Fe、K、Mg、Mn、Mo、Na、Rb、Sb、Sc、Sr、Th、U 和 Zn）在内的 21 种矿物质。结果表明，矿物质元素的浓度接近 FAO 的最低建议值。此外，结果还显示出显著的抗炎活性。生成的数据可以为制药工业和医学研究提供有价值的信息来源。这些结果表明，未成熟果实提取物具有适当的潜力，可以在广泛的背景下用作多功能用途的药物，以及治疗其他生理疾病的天然药物。
