Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Department of Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
World J Gastroenterol. 2022 Dec 21;28(47):6716-6731. doi: 10.3748/wjg.v28.i47.6716.
Coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has escalated into a global tragedy afflicting human health, life, and social governance. Through the increasing depth of research and a better understanding of this disease, it has been ascertained that, in addition to the lungs, SARS-CoV-2 can also induce injuries to other organs including the liver. Liver injury is a common clinical manifestation of COVID-19, particularly in severe cases, and is often associated with a poorer prognosis and higher severity of COVID-19. This review focuses on the general existing information on liver injury caused by COVID-19, including risk factors and subpopulations of liver injury in COVID-19, the association between preexisting liver diseases and the severity of COVID-19, and the potential mechanisms by which SARS-CoV-2 affects the liver. This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.
新型冠状病毒肺炎（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的，已演变为影响人类健康、生命和社会治理的全球性悲剧。通过对该疾病的研究不断深入，我们越来越清楚地认识到，除了肺部，SARS-CoV-2 还可能导致包括肝脏在内的其他器官受损。肝损伤是 COVID-19 的常见临床症状，尤其是在重症病例中，常与预后较差和 COVID-19 严重程度较高有关。本综述重点关注 COVID-19 引起的肝损伤的一般现有信息，包括 COVID-19 中肝损伤的危险因素和亚人群、原有肝脏疾病与 COVID-19 严重程度的关系，以及 SARS-CoV-2 影响肝脏的潜在机制。本综述可能为 COVID-19 相关肝损伤的治疗和预防策略的制定提供一些有用的信息。
