Department of Psychiatry, Mount Carmel Hospital, Attard, Malta
Mater Dei Hospital, Msida, Malta.
BMJ Case Rep. 2023 Jan 10;16(1):e253547. doi: 10.1136/bcr-2022-253547.
We present a case of a young man who developed sudden deterioration in his physical and mental state whilst being treated as an inpatient for substance-induced psychosis. This deterioration was manifested by sudden disorientation, change in behaviour and visual hallucinations. It was only after excluding other potential causes that this presentation was attributed to the regular administration of procyclidine that was being used to counteract the extrapyramidal side effects from antipsychotics. The patient showed a dramatic improvement on stopping procyclidine. This case highlights the importance of awareness of rare adverse drug reactions and the resultant distressing effect for the patient himself.
我们报告了一例年轻男性患者，他在因物质所致精神障碍住院治疗时突然出现精神和身体状态恶化。这种恶化表现为定向障碍、行为改变和幻视。只有排除其他潜在原因后，才将这种表现归因于常规给予的丙环定，以对抗抗精神病药物的锥体外系副作用。停止使用丙环定后，患者的病情显著改善。该病例强调了认识罕见药物不良反应及其对患者自身造成的痛苦影响的重要性。
