Moroishi Yuka, Salas Lucas A, Zhou Jie, Baker Emily R, Hoen Anne G, Everson Todd M, Marsit Carmen J, Madan Juliette, Gui Jiang, Karagas Margaret R
Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
iScience. 2022 Dec 17;26(1):105833. doi: 10.1016/j.isci.2022.105833. eCollection 2023 Jan 20.
During infancy, the interplay between the developing immune system and the microbiome is critical. We examined whether blood immune cell composition at birth in the umbilical cord (inferred by DNA methylation profiling) related to the early infant gut microbiome (assessed by 16S rRNA gene sequencing) among 73 infants in the New Hampshire Birth Cohort Study. We used generalized estimating equations and controlled for false discovery rate to select microbial taxa associated with immune cells. We found associations between the infant gut microbiome and immune cells, including a positive association between B cells and , a negative association between natural killer cells and , and a positive association between granulocytes and . Our findings give clues that immune profiles at the time of birth as measured in umbilical cord blood are associated with the development of the gut microbiome in early life.
在婴儿期，发育中的免疫系统与微生物群之间的相互作用至关重要。在新罕布什尔州出生队列研究的73名婴儿中，我们研究了脐带血出生时的血液免疫细胞组成（通过DNA甲基化谱推断）是否与早期婴儿肠道微生物群（通过16S rRNA基因测序评估）相关。我们使用广义估计方程并控制错误发现率，以选择与免疫细胞相关的微生物分类群。我们发现婴儿肠道微生物群与免疫细胞之间存在关联，包括B细胞与 之间的正相关、自然杀伤细胞与 之间的负相关以及粒细胞与 之间的正相关。我们的研究结果表明，脐带血中测得的出生时免疫谱与生命早期肠道微生物群的发育有关。
