玻璃体细胞的起源、结构与成像。
Hyalocyte origin, structure, and imaging.
作者信息
Wieghofer Peter, Engelbert Michael, Chui Toco Yp, Rosen Richard B, Sakamoto Taiji, Sebag J
机构信息
Cellular Neuroanatomy, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg, Universitätsstraße 2, 86159 Augsburg, Germany.
Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA.
出版信息
Expert Rev Ophthalmol. 2022;17(4):233-248. doi: 10.1080/17469899.2022.2100762. Epub 2022 Sep 6.
Abstract
INTRODUCTION
Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19 century. Despite this, knowledge about their origin, turnover, and dynamics is limited.
AREAS COVERED
Historically, initial studies on the origin of hyalocytes used light and electron microscopy. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes The shared ontogeny with retinal microglia and their eventual interdependence as well as differences will be discussed.
EXPERT OPINION
Owing to a common origin as myeloid cells, hyalocytes and retinal microglia have similarities, but hyalocytes appear to be distinct as resident macrophages of the vitreous body.
摘要
引言
自19世纪中叶以来，玻璃体细胞就被认为是玻璃体的常驻组织巨噬细胞。尽管如此，关于它们的起源、更新和动态变化的知识仍然有限。
涵盖领域
从历史上看，对玻璃体细胞起源的初步研究使用了光学显微镜和电子显微镜。将描述包括啮齿动物和人类在内的跨物种现代研究。现在有了新的成像技术来研究人类玻璃体细胞。将讨论它们与视网膜小胶质细胞共同的个体发生、最终的相互依存关系以及差异。
专家观点
由于作为髓样细胞有共同的起源，玻璃体细胞和视网膜小胶质细胞有相似之处，但玻璃体细胞作为玻璃体的常驻巨噬细胞似乎是独特的。
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