Tong Aijun, Wu Weihao, Chen Zhengxin, Wen Jiahui, Jia Ruibo, Liu Bin, Cao Hui, Zhao Chao
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
National Engineering Research Center of Juncao, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Curr Res Food Sci. 2022 Dec 27;6:100427. doi: 10.1016/j.crfs.2022.100427. eCollection 2023.
triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia. The effects of GP on high-fat diet (HFD)-induced hyperlipidemia and gut microbiota modulation were determined in rats. Ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS-MS) indicated that GP were enriched with ganoderic acids G, B, H, A, and F. After feeding with GP supplementation, serum lipid levels including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol were significantly decreased in hyperlipidemic rats. Furthermore, administration of GP also has reversed the HFD-induced gut microbiota dysbiosis, including a significant increase in and reduced proportion of The result above suggests that GP would be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidemia.
据报道，三萜类化合物（GP）有助于预防和改善高脂血症。肠道微生物群的调节被认为是潜在因素，也是预防和治疗高脂血症的一种新措施。在大鼠中确定了GP对高脂饮食（HFD）诱导的高脂血症和肠道微生物群调节的影响。超高效液相色谱串联四极杆飞行时间质谱（UPLC-QTOF MS-MS）表明，GP富含灵芝酸G、B、H、A和F。在补充GP喂养后，高脂血症大鼠的血清脂质水平，包括总甘油三酯、总胆固醇和低密度脂蛋白胆固醇显著降低。此外，给予GP还逆转了HFD诱导的肠道微生物群失调，包括[此处原文缺失具体微生物名称]的显著增加和[此处原文缺失具体微生物名称]比例的降低。上述结果表明，GP有望开发成为一种功能性食品，以改善脂质代谢紊乱和高脂血症。
