Fujimori M, Imamura T, Yamashita H, Hirono N, Ikejiri Y, Shimomura T, Mori E
Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Alzheimer Dis Assoc Disord. 1998 Sep;12(3):163-6. doi: 10.1097/00002093-199809000-00007.
We examined the relation of age at onset and visuocognitive disturbances in Alzheimer disease (AD) using a large sample of patients, quantitative neuropsychological measures, and multivariate statistics controlling for gender, education, stage of dementia, and disease duration. Significant positive coefficients were obtained with forward and backward digit and visual spans, visual counting, copying Rey complex figure, and block design task. The results indicated that patients with early-onset AD performed worse than late-onset AD patients on these tasks. There was no significant effect of age at onset on identification of overlapping figures, visual form discrimination, or Raven's colored progressive matrices. These findings confirm the greater attentional and visuospatial impairments in early onset patients when these confounding factors were controlled for, although no significant effect of age at onset in visuoperceptual function was observed.
我们使用大量患者样本、定量神经心理学测量方法以及控制性别、教育程度、痴呆阶段和病程的多变量统计分析，研究了阿尔茨海默病（AD）发病年龄与视觉认知障碍之间的关系。在前向和后向数字广度、视觉广度、视觉计数、临摹雷氏复杂图形以及积木设计任务中获得了显著的正系数。结果表明，早发性AD患者在这些任务上的表现比晚发性AD患者更差。发病年龄对重叠图形识别、视觉形式辨别或瑞文彩色渐进矩阵没有显著影响。这些发现证实，在控制了这些混杂因素后，早发性患者存在更严重的注意力和视觉空间损害，尽管未观察到发病年龄对视觉感知功能有显著影响。
