Department of Biochemistry & Molecular Biology, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Curr Med Chem. 2023;30(38):4340-4354. doi: 10.2174/0929867330666230111125141.
Long non-coding RNA (lncRNA) is a kind of biomolecule that can regulate important life activities such as cell proliferation, apoptosis, differentiation, aging, and body development. It has been found that lncRNAs are closely related to various diseases. In cardiovascular diseases, lncRNAs affect the expression level of related genes in atherosclerotic plaques, which are closely related to endothelial dysfunction, smooth muscle cell proliferation, macrophage dysfunction, abnormal lipid metabolism, and cellular autophagy, thus participating in regulating the occurrence and development of AS. In view of this, investigating the role of lncRNAs in regulating cardiac gene networks on cardiovascular system diseases has attracted much clinical attention and may be a novel target for AS therapy. This paper focuses on lncRNAs related to AS, explores the relationship between lncRNAs and AS, suggests the role of lncRNAs in the prevention and treatment of AS, and expects the application of more lncRNAs as the marker in the clinical diagnosis and treatment of AS.
长非编码 RNA（lncRNA）是一种能够调节细胞增殖、凋亡、分化、衰老和机体发育等重要生命活动的生物分子。现已发现 lncRNAs 与多种疾病密切相关。在心血管疾病中，lncRNAs 影响动脉粥样硬化斑块中相关基因的表达水平，与内皮功能障碍、平滑肌细胞增殖、巨噬细胞功能障碍、脂质代谢异常和细胞自噬密切相关，从而参与调节 AS 的发生和发展。鉴于此，研究 lncRNAs 在调节心血管系统疾病心脏基因网络中的作用引起了临床的广泛关注，可能成为 AS 治疗的新靶点。本文重点关注与 AS 相关的 lncRNAs，探讨 lncRNAs 与 AS 的关系，提出 lncRNAs 在 AS 防治中的作用，期望更多的 lncRNAs 作为 AS 临床诊断和治疗的标志物得到应用。
