Department of Biotechnology, Periyar University, Centre for Postgraduate and Research Studies, Dharmapuri, Tamil Nadu 635205, India.
Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India.
Mol Biochem Parasitol. 2023 Feb;253:111543. doi: 10.1016/j.molbiopara.2023.111543. Epub 2023 Jan 13.
The mosquito gut microbiota is vital to the proper functioning of the host organism. Mosquitoes may benefit from this microbiota in their guts because it promotes factors including blood digestion, fecundity, metamorphosis, and living habitat and inhibits malarial parasites (Plasmodium) growth or transmission. In this overview, we analyzed how mosquitoes acquire their gut microbiota, characterized those bacteria, and discussed the functions they provide. We also investigated the effects of microbiota on malaria vectors, with a focus on the mosquito species Anopheles, as well as the relationship between microbiota and Plasmodium, the aspects in which microbiota influences Plasmodium via immune response, metabolism, and redox mechanisms, and the strategies in which gut bacteria affect the life cycle of malaria vectors and provide the ability to resist insecticides. This article explores the difficulties in studying triadic interactions, such as the interplay between Mosquitoes, Malarial parasite, and the Microbiota that dwell in the mosquitoes' guts, and need additional research for a better understanding of these multiple connections to implement an exact vector control strategies using Gut microbiota in malaria control.
蚊虫肠道微生物群对于宿主生物的正常运作至关重要。蚊虫可能从肠道中的微生物群中受益，因为它促进了包括血液消化、繁殖力、变态和生活栖息地在内的因素，并抑制疟原虫（疟原虫）的生长或传播。在这篇综述中，我们分析了蚊子是如何获得肠道微生物群的，描述了这些细菌，并讨论了它们提供的功能。我们还研究了微生物群对疟疾媒介的影响，重点是疟蚊属的蚊子，以及微生物群与疟原虫之间的关系，在这些关系中，微生物群通过免疫反应、代谢和氧化还原机制影响疟原虫，以及肠道细菌影响疟疾媒介生命周期和提供抗杀虫剂能力的策略。本文探讨了研究三方相互作用（如蚊子、疟原虫和栖息在蚊子肠道中的微生物群之间的相互作用）的困难，需要进一步研究以更好地理解这些多重联系，以便利用肠道微生物群实施精确的病媒控制策略来控制疟疾。
