Microbiota of Insect Vectors Group, Institut Pasteur de la Guyane, Cayenne, French Guiana, France.
Parasites and Insect Vectors Department, Institut Pasteur, Paris, France.
Parasit Vectors. 2018 Mar 20;11(1):200. doi: 10.1186/s13071-018-2784-x.
The microbiota of Anopheles mosquitoes interferes with mosquito infection by Plasmodium and influences mosquito fitness, therefore affecting vectorial capacity. This natural barrier to malaria transmission has been regarded with growing interest in the last 20 years, as it may be a source of new transmission-blocking strategies. The last decade has seen tremendous progress in the functional characterisation of the tripartite interactions between the mosquito, its microbiota and Plasmodium parasites. In this review, we provide insights into the effects of the mosquito microbiota on Plasmodium infection and on mosquito physiology, and on how these aspects together influence vectorial capacity. We also discuss three current challenges in the field, namely the need for a more relevant microbiota composition in experimental mosquitoes involved in vector biology studies, for a better characterisation of the non-bacterial microbiota, and for further functional studies of the microbiota present outside the gut.
按蚊的微生物群会干扰疟原虫对蚊子的感染，并影响蚊子的适应能力，从而影响媒介传播能力。过去 20 年来，这种疟疾传播的天然屏障引起了越来越多的关注，因为它可能是一种新的阻断传播策略的来源。在过去的十年中，人们在蚊子、其微生物群和疟原虫寄生虫之间的三方相互作用的功能特征方面取得了巨大的进展。在这篇综述中，我们深入探讨了蚊子微生物群对疟原虫感染和蚊子生理学的影响，以及这些方面如何共同影响媒介传播能力。我们还讨论了该领域的三个当前挑战，即需要在参与蚊媒生物学研究的实验性蚊子中更相关的微生物群组成，需要更好地描述非细菌微生物群，以及需要对肠道外存在的微生物群进行进一步的功能研究。
