Simone D A, Ngeow J Y, Putterman G J, LaMotte R H
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510.
Brain Res. 1987 Aug 18;418(1):201-3. doi: 10.1016/0006-8993(87)90982-6.
Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 micrograms, given in a constant volume of 10 microliter. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.
皮内注射到人体前臂的辣椒素降低了注射部位对热的痛阈。在10微升恒定体积内给予0.1 - 100微克的剂量范围内，痛觉过敏的程度和持续时间均呈剂量依赖性。因此，辣椒素可能是研究痛觉过敏神经机制的一种有用工具。
