Du Li, Liu Jianghong, Jin Cheng, Ma Yuan, Yin Linlin, Man Sailimai, Li Shijun, Li Liming, Ning Yi, Zhang Xinghu
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Atheroscler Plus. 2021 Aug 13;44:25-30. doi: 10.1016/j.athplu.2021.08.004. eCollection 2021 Oct.
The role of () infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults.
We recruited 108,210 Chinese adults who participated in a standard medical screening with both carotid ultrasonic examination and C-urea breath test for infection from two Chinese cohorts. A total of 93,915 adults were included in the analysis after excluding participants with cardiovascular disease (CVD) and carotid plaques at baseline. Hazard ratio (HR) for developing carotid plaques by infection was analyzed using the Cox proportional hazard model, with sociodemographic and clinical factors adjusted. Findings across cohorts were pooled by meta-analyses.
11,208 (13.13%) participants occurred carotid plaques at a median follow-up of 20 months in the MN cohort, while 1279 (14.95%) participants occurred carotid plaques at a median follow-up of 24 months in the MJ cohort. Compare with participants without infection, participants with infection were more likely to occur carotid plaques. After adjusting for age, sex, annual personal income, body mass index, blood pressure, blood glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and estimated glomerular filtration rate, the HR was 1.04 (95%CI: 1.01-1.08). After further adjusting for education level, marital status, smoking status, alcohol drinking status, physical activity, and family history of CVD, the HR changed minimally. Additional sensitivity analyses confirmed the robustness of the results. Significant interactions of age, sex, blood pressure, blood glucose, or chronic inflammation were not observed in this research.
infection was associated with carotid plaque onset in a large number of Chinese adults without previous CVD. These data suggested that the prevention of infection may reduce the burden of carotid atherosclerosis.
（）感染在颈动脉粥样硬化中的作用仍不一致，有时存在争议。我们旨在确定在大量中国成年人中，（）感染是否与颈动脉粥样硬化斑块相关。
我们从两个中国队列中招募了108,210名参与标准医学筛查的中国成年人，他们均接受了颈动脉超声检查和用于检测（）感染的碳 - 尿素呼气试验。在排除基线时患有心血管疾病（CVD）和颈动脉斑块的参与者后，共有93,915名成年人纳入分析。使用Cox比例风险模型分析（）感染导致颈动脉斑块形成的风险比（HR），并对社会人口统计学和临床因素进行调整。通过荟萃分析汇总各队列的研究结果。
在MN队列中，11,208名（13.13%）参与者在中位随访20个月时出现颈动脉斑块，而在MJ队列中，1279名（14.95%）参与者在中位随访24个月时出现颈动脉斑块。与未感染（）的参与者相比，感染（）的参与者更易出现颈动脉斑块。在调整年龄、性别、个人年收入、体重指数、血压、血糖、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、高敏C反应蛋白和估计肾小球滤过率后，HR为1.04（95%CI：1.01 - 1.08）。在进一步调整教育水平、婚姻状况、吸烟状况、饮酒状况、身体活动和CVD家族史后，HR变化极小。额外的敏感性分析证实了结果的稳健性。本研究未观察到年龄、性别、血压、血糖或慢性炎症的显著交互作用。
在大量既往无CVD的中国成年人中，（）感染与颈动脉斑块的发生相关。这些数据表明，预防（）感染可能减轻颈动脉粥样硬化的负担。
