Marruganti Crystal, Baima Giacomo, Aimetti Mario, Grandini Simone, Sanz Mariano, Romandini Mario
Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
J Clin Periodontol. 2023 Apr;50(4):418-429. doi: 10.1111/jcpe.13779. Epub 2023 Jan 27.
To study the epidemiological association between periodontitis and low cognitive performance among older adults, within a representative sample of the U.S.
Data from 2086 older adults (≥60 years old), representative of 77.1 million people, were retrieved from the NHANES 2011-2014 database. Periodontitis cases were identified and classified according to the AAP/CDC criteria (mild, moderate, and severe). Cognitive function was assessed through the Consortium to Establish a Registry for Alzheimer's disease (CERAD), the animal fluency test (AFT), the digit symbol substitution test (DSST), and the global cognition score. The lowest non-survey weighted quartile for each cognitive test was defined as low cognitive performance. Simple and multiple regression analyses were performed.
Moderate and severe periodontitis were significantly associated with a low DSST performance (OR = 1.66 and OR = 2.97, respectively). Each millimetre increase in mean CAL was associated with a lower AFT (OR = 1.44), DSST (OR = 1.86), and global cognition (OR = 1.50) performance.
The findings of the present study suggest the existence of an independent association between periodontitis and low cognitive performance among older adults (≥60 years old).
在美国具有代表性的样本中，研究老年人牙周炎与认知能力低下之间的流行病学关联。
从2011 - 2014年美国国家健康与营养检查调查（NHANES）数据库中检索了2086名老年人（≥60岁）的数据，这些数据代表了7710万人。根据美国牙周病学会/美国疾病控制与预防中心（AAP/CDC）标准确定并分类牙周炎病例（轻度、中度和重度）。通过阿尔茨海默病注册协会（CERAD）、动物流畅性测试（AFT）、数字符号替换测试（DSST）和整体认知得分评估认知功能。每个认知测试中未加权调查的最低四分位数被定义为认知能力低下。进行了简单和多元回归分析。
中度和重度牙周炎与较低的DSST表现显著相关（OR分别为1.66和2.97）。平均临床附着丧失（CAL）每增加1毫米，与较低的AFT（OR = 1.44）、DSST（OR = 1.86）和整体认知（OR = 1.50）表现相关。
本研究结果表明，老年人（≥60岁）牙周炎与认知能力低下之间存在独立关联。
