肝硬化患者的肌肉减少症：当前认知与未来方向
Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions.
作者信息
Warner Ii Edgewood R, Satapathy Sanjaya K
机构信息
Department of Medicine, Donald and Barbara Zucker School of Medicine/Northwell Health, 300 Community Drive, Manhasset, NY, 11030, USA.
Division of Hepatology and Northwell Health Center for Liver Diseases and Transplantation, Department of Medicine, Donald and Barbara Zucker School of Medicine/Northwell Health, 300 Community Drive, Manhasset, NY, 11030, USA.
出版信息
J Clin Exp Hepatol. 2023 Jan-Feb;13(1):162-177. doi: 10.1016/j.jceh.2022.06.005. Epub 2022 Jun 27.
Abstract
Cirrhosis predisposes to abnormalities in energy, hormonal, and immunological homeostasis. Disturbances in these metabolic processes create susceptibility to sarcopenia or pathological muscle wasting. Sarcopenia is prevalent in cirrhosis and its presence portends significant adverse outcomes including the length of hospital stay, infectious complications, and mortality. This highlights the importance of identification of at-risk individuals with early nutritional, therapeutic and physical therapy intervention. This manuscript summarizes literature relevant to sarcopenia in cirrhosis, describes current knowledge, and elucidates possible future directions.
摘要
肝硬化易导致能量、激素和免疫内稳态异常。这些代谢过程的紊乱会使人易患肌肉减少症或病理性肌肉萎缩。肌肉减少症在肝硬化患者中很常见，其存在预示着包括住院时间、感染并发症和死亡率在内的重大不良后果。这凸显了识别有风险个体并进行早期营养、治疗和物理治疗干预的重要性。本手稿总结了与肝硬化患者肌肉减少症相关的文献，描述了当前的认识，并阐明了可能的未来方向。
相似文献
1
Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions.
J Clin Exp Hepatol. 2023 Jan-Feb;13(1):162-177. doi: 10.1016/j.jceh.2022.06.005. Epub 2022 Jun 27.
2
Nutrition and Muscle in Cirrhosis.
J Clin Exp Hepatol. 2017 Dec;7(4):340-357. doi: 10.1016/j.jceh.2017.11.001. Epub 2017 Nov 8.
3
Sarcopenia and chronic liver diseases.
Expert Rev Gastroenterol Hepatol. 2018 Dec;12(12):1229-1244. doi: 10.1080/17474124.2018.1534586. Epub 2018 Oct 16.
4
Validating muscle mass cutoffs of four international sarcopenia-working groups in Japanese people using DXA and BIA.
J Cachexia Sarcopenia Muscle. 2021 Aug;12(4):1000-1010. doi: 10.1002/jcsm.12732. Epub 2021 Jun 7.
5
Sarcopenia: Clinical implications in ovarian cancer, diagnosis, etiology, and management.
Sports Med Health Sci. 2020 Oct 14;2(4):202-210. doi: 10.1016/j.smhs.2020.10.001. eCollection 2020 Dec.
6
Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease.
JHEP Rep. 2020 Aug 15;2(6):100171. doi: 10.1016/j.jhepr.2020.100171. eCollection 2020 Dec.
7
Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: results from the I-Lan longitudinal aging study.
J Am Med Dir Assoc. 2013 Jul;14(7):528.e1-7. doi: 10.1016/j.jamda.2013.03.019. Epub 2013 May 10.
8
A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients.
JHEP Rep. 2021 Jun 15;3(4):100323. doi: 10.1016/j.jhepr.2021.100323. eCollection 2021 Aug.
9
Blockade of angiotensin II modulates insulin-like growth factor 1-mediated skeletal muscle homeostasis in experimental steatohepatitis.
Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119649. doi: 10.1016/j.bbamcr.2023.119649. Epub 2023 Dec 12.
10
Screening Sarcopenia in Community-Dwelling Older Adults: SARC-F vs SARC-F Combined With Calf Circumference (SARC-CalF).
J Am Med Dir Assoc. 2018 Mar;19(3):277.e1-277.e8. doi: 10.1016/j.jamda.2017.12.016.
引用本文的文献
1
Impacts of salt restriction on nutritional status, sarcopenia, and mortality of cirrhotic patients with ascites.
BMC Gastroenterol. 2025 Jul 15;25(1):521. doi: 10.1186/s12876-025-03830-1.
2
Sarcopenia and frailty: An in-depth analysis of the pathophysiology and effect on liver transplant candidates.
World J Hepatol. 2025 May 27;17(5):106182. doi: 10.4254/wjh.v17.i5.106182.
3
Dynamic skeletal muscle loss and its predictive role on 90-day mortality in patients with acute-on-chronic liver failure.
Front Nutr. 2025 Feb 27;12:1446265. doi: 10.3389/fnut.2025.1446265. eCollection 2025.
4
Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review.
Nutrients. 2024 Jan 31;16(3):427. doi: 10.3390/nu16030427.
5
Frailty in end-stage liver disease: Understanding pathophysiology, tools for assessment, and strategies for management.
World J Gastroenterol. 2023 Dec 14;29(46):6028-6048. doi: 10.3748/wjg.v29.i46.6028.
6
Liver Transplantation: Protocol for Recipient Selection, Evaluation, and Assessment.
J Clin Exp Hepatol. 2023 Sep-Oct;13(5):841-853. doi: 10.1016/j.jceh.2023.04.002. Epub 2023 Apr 17.
7
Evaluation and Management of Nutritional Consequences of Chronic Liver Diseases.
Nutrients. 2023 Aug 7;15(15):3487. doi: 10.3390/nu15153487.
8
Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota.
World J Gastroenterol. 2023 Jul 21;29(27):4236-4251. doi: 10.3748/wjg.v29.i27.4236.
本文引用的文献
1
A narrative review of nutritional abnormalities, complications, and optimization in the cirrhotic patient.
Transl Gastroenterol Hepatol. 2022 Jan 25;7:5. doi: 10.21037/tgh-20-325. eCollection 2022.
2
Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.
J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):858-871. doi: 10.1002/jcsm.12934. Epub 2022 Feb 16.
3
Impact of Sarcopenia on the Severity of the Liver Damage in Patients With Non-alcoholic Fatty Liver Disease.
Front Nutr. 2022 Jan 17;8:774030. doi: 10.3389/fnut.2021.774030. eCollection 2021.
4
Sarcopenia defined by psoas muscle index independently predicts long-term survival after living donor liver transplantation in male recipients.
Quant Imaging Med Surg. 2022 Jan;12(1):215-228. doi: 10.21037/qims-21-314.
5
Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update.
Front Med (Lausanne). 2021 Aug 9;8:689042. doi: 10.3389/fmed.2021.689042. eCollection 2021.
6
Validating muscle mass cutoffs of four international sarcopenia-working groups in Japanese people using DXA and BIA.
J Cachexia Sarcopenia Muscle. 2021 Aug;12(4):1000-1010. doi: 10.1002/jcsm.12732. Epub 2021 Jun 7.
7
The role of skeletal muscle in the pathogenesis of altered concentrations of branched-chain amino acids (valine, leucine, and isoleucine) in liver cirrhosis, diabetes, and other diseases.
Physiol Res. 2021 Jul 12;70(3):293-305. doi: 10.33549/physiolres.934648. Epub 2021 May 12.
8
The Impact of Frailty, Sarcopenia, and Malnutrition on Liver Transplant Outcomes.
Clin Liver Dis (Hoboken). 2021 May 1;17(4):271-276. doi: 10.1002/cld.1043. eCollection 2021 Apr.
9
Emerging Treatment Options for Sarcopenia in Chronic Liver Disease.
Life (Basel). 2021 Mar 17;11(3):250. doi: 10.3390/life11030250.
10
Malnutrition in cirrhosis: More food for thought.
World J Hepatol. 2020 Nov 27;12(11):883-896. doi: 10.4254/wjh.v12.i11.883.
Zotero 插件