An Chuanfeng, Li Hanting, Zhao Yanqiu, Zhang Shiying, Zhao Yuan, Zhang Yujie, Yang Jianhua, Zhang Lijun, Ren Changle, Zhang Yang, Liu Jia, Wang Huanan
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical school, Shenzhen 518060, PR China; State key laboratory of fine chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Bioengineering, Dalian University of Technology, Dalian 116023, PR China; Central Laboratory, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, PR China & Longgang District People's Hospital of Shenzhen.
State key laboratory of fine chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Bioengineering, Dalian University of Technology, Dalian 116023, PR China.
Int J Biol Macromol. 2023 Mar 15;231:123307. doi: 10.1016/j.ijbiomac.2023.123307. Epub 2023 Jan 15.
Hyaluronic acid (HA) is an important type of naturally derived carbohydrate polymer with specific polysaccharide macromolecular structures and multifaceted biological functions, including biocompatibility, low immunogenicity, biodegradability, and bioactivity. Specifically, HA hydrogels in a microscopic scale have been widely used for biomedical applications, such as drug delivery, tissue engineering, and medical cosmetology, considering their superior properties outperforming the more conventional monolithic hydrogels in network homogeneity, degradation profile, permeability, and injectability. Herein, we reviewed the recent progress in the preparation and applications of HA microgels in biomedical fields. We first summarized the fabrication of HA microgels by focusing on the different crosslinking/polymerization schemes for HA gelation and the miniaturized fabrication techniques for producing HA-based microparticles. We then highlighted the use of HA-based microgels for different applications in regenerative medicine, including cartilage repair, bioactive delivery, diagnostic imaging, modular tissue engineering. Finally, we discussed the challenges and future perspectives in bridging the translational gap in the utilization of HA-based microgels in regenerative medicine.
透明质酸（HA）是一种重要的天然衍生碳水化合物聚合物，具有特定的多糖大分子结构和多方面的生物学功能，包括生物相容性、低免疫原性、生物可降解性和生物活性。具体而言，微观尺度的HA水凝胶因其在网络均匀性、降解特性、渗透性和可注射性等方面具有优于传统整体水凝胶的卓越性能，已被广泛应用于生物医学领域，如药物递送、组织工程和医学美容。在此，我们综述了HA微凝胶在生物医学领域制备和应用的最新进展。我们首先通过聚焦于HA凝胶化的不同交联/聚合方案以及用于制备基于HA的微粒的小型化制造技术，总结了HA微凝胶的制备方法。然后，我们强调了基于HA的微凝胶在再生医学中的不同应用，包括软骨修复、生物活性递送、诊断成像、模块化组织工程。最后，我们讨论了在弥合基于HA的微凝胶在再生医学应用中的转化差距方面所面临的挑战和未来前景。
