Monton Chaowalit, Chuanchom Panupong, Popanit Puwadon, Settharaksa Sukanya, Pathompak Pathamaporn
Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
Acta Pharm. 2020 Dec 31;71(3):445-457. doi: 10.2478/acph-2021-0025. Print 2021 Sep 1.
The aim of this work was to optimize the mass ratio of three plants' rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected plants were , and . The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of and in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that alone exhibited the highest antioxidant activity.
本研究旨在采用单纯形格子设计优化三种植物根茎的质量比，以获得最高的姜黄素含量和抗氧化活性。所选植物为[植物名称1]、[植物名称2]和[植物名称3]。研究中应用了单纯形格子设计。采用高效液相色谱法测定了各姜黄素（姜黄素、去甲氧基姜黄素和双去甲氧基姜黄素）及总姜黄素含量。单独使用[植物名称1]时，双去甲氧基姜黄素和去甲氧基姜黄素含量最高。质量比为72:28%的[植物名称2]和[植物名称3]混合物姜黄素含量最高。结果表明，单独使用[植物名称1]时抗氧化活性最高。
