Suksaeree Jirapornchai, Monton Chaowalit
Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
Int J Food Sci. 2024 Mar 25;2024:4566123. doi: 10.1155/2024/4566123. eCollection 2024.
Salisb. contains a high content of curcuminoids, which can be utilized for cosmetic purposes. The objective of this study was to optimize the extraction conditions of rhizomes in castor oil to maximize curcuminoid content using a simple and environmentally friendly microwave-assisted extraction method. A 3 full factorial design was employed, with two factors-microwave power and time-varying between 600-800 W and 30-90 s, respectively. Five responses were monitored, including extraction yield, bisdemethoxycurcumin, demethoxycurcumin, curcumin, and total curcuminoid contents. The results demonstrated that increasing microwave power and time led to an increase in all five responses. The optimal condition, which simultaneously maximized extraction yield and total curcuminoid content, was achieved at a microwave power of 800 W for 90 s. This condition resulted in an extraction yield of 71.020%, bisdemethoxycurcumin content of 0.036%, demethoxycurcumin content of 0.210%, curcumin content of 0.080%, and total curcuminoid content of 0.326%. The computer program accurately predicted the results with a percentage error of less than 2%. Stability data revealed that the total curcuminoid content remained stable with a percentage remaining above 90% when stored at 4°C, 30°C ± 75%RH, and 40° ± 75%RH for three months. In summary, this study successfully applied a full factorial design to maximize curcuminoid extraction from rhizomes using an environmentally friendly microwave-assisted extraction method for cosmetic purposes.
姜黄含有高含量的姜黄素类化合物，可用于化妆品用途。本研究的目的是使用简单且环保的微波辅助萃取方法，优化蓖麻油中根茎的萃取条件，以使姜黄素类化合物含量最大化。采用三因素全因子设计，两个因素——微波功率和时间，分别在600 - 800瓦和30 - 90秒之间变化。监测了五个响应指标，包括萃取产率、双去甲氧基姜黄素、去甲氧基姜黄素、姜黄素和总姜黄素类化合物含量。结果表明，增加微波功率和时间会导致所有五个响应指标增加。在微波功率800瓦、时间90秒时实现了同时使萃取产率和总姜黄素类化合物含量最大化的最佳条件。此条件下萃取产率为71.020%，双去甲氧基姜黄素含量为0.036%，去甲氧基姜黄素含量为0.210%，姜黄素含量为0.080%，总姜黄素类化合物含量为0.326%。计算机程序准确预测了结果，百分比误差小于2%。稳定性数据显示，在4°C、30°C ± 75%相对湿度和40°C ± 75%相对湿度下储存三个月时，总姜黄素类化合物含量保持稳定，剩余百分比高于90%。总之，本研究成功应用全因子设计，采用环保的微波辅助萃取方法从根茎中最大化提取姜黄素类化合物用于化妆品用途。
